Experience-dependent plasticity of rat barrel cortex

Redistribution of activity across barrel-columns

Mikhail A. Lebedev, Giovanni Mirabella, Irina Erchova, Mathew E. Diamond

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The redistribution of neuronal activity across rat barrel cortex following an alteration in whisker usage has been investigated. In adult rats, two mystacial vibrissae - D2 and one neighbor, D1 or D3 were left intact while all other vibrissae on that side of the snout were clipped. Neurons in contralateral barrel cortex were sampled with a microelectrode array 3.5 days later. Stimulation of clipped vibrissae produced a narrow spatial distribution of cortical activity, whereas stimulation of intact vibrissae produced a widened spatial distribution. Simultaneous recordings from multiple cortical barrel-columns suggest that changes in the effective connectivity between barrel-columns may partially account for this redistribution of sensory responses. Evidence is also presented for a second mechanism, a release from inhibition in sensory-deprived cortical areas. A model is therefore proposed where these two mechanisms operate together to regulate the cortical distribution of evoked activity.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalCerebral Cortex
Volume10
Issue number1
Publication statusPublished - Jan 2000

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Vibrissae
Microelectrodes
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

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Experience-dependent plasticity of rat barrel cortex : Redistribution of activity across barrel-columns. / Lebedev, Mikhail A.; Mirabella, Giovanni; Erchova, Irina; Diamond, Mathew E.

In: Cerebral Cortex, Vol. 10, No. 1, 01.2000, p. 23-31.

Research output: Contribution to journalArticle

Lebedev, Mikhail A. ; Mirabella, Giovanni ; Erchova, Irina ; Diamond, Mathew E. / Experience-dependent plasticity of rat barrel cortex : Redistribution of activity across barrel-columns. In: Cerebral Cortex. 2000 ; Vol. 10, No. 1. pp. 23-31.
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