Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression

Vikram Jakkamsetti, Nien Pei Tsai, Christina Gross, Gemma Molinaro, Katie A. Collins, Ferdinando Nicoletti, KuanH Wang, Pavel Osten, Gary J. Bassell, Jay R. Gibson, KimberlyM Huber

Research output: Contribution to journalArticle

Abstract

A novel experience induces the Arc/Arg3.1 gene as well as plasticity of CA1 neural networks. To understand how these are linked, we briefly exposed GFP reporter mice of Arc transcription to a novel environment. Excitatory synaptic function of CA1 neurons with recent invivo Arc induction (. ArcGFP+) was similar to neighboring noninduced neurons. However, in response to group 1 metabotropic glutamate receptor (mGluR) activation, ArcGFP+ neurons preferentially displayed long-term synaptic depression (mGluR-LTD) and robust increases in dendritic Arc protein. mGluR-LTD in ArcGFP+ neurons required rapid protein synthesis and Arc, suggesting that dendritic translation of Arc underlies the priming of mGluR-LTD. In support of this idea, novelty exposure increased Arc messenger RNA in CA1 dendrites and promoted mGluR-induced translation of Arc inhippocampal synaptoneurosomes. Repeated experience suppressed synaptic transmission onto ArcGFP+ neurons and occluded mGluR-LTD exvivo. mGluR-LTD priming in neurons with similar Arc activation history may contribute to encoding a novel environment

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalNeuron
Volume80
Issue number1
DOIs
Publication statusPublished - Oct 2 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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    Jakkamsetti, V., Tsai, N. P., Gross, C., Molinaro, G., Collins, K. A., Nicoletti, F., Wang, K., Osten, P., Bassell, G. J., Gibson, J. R., & Huber, K. (2013). Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression. Neuron, 80(1), 72-79. https://doi.org/10.1016/j.neuron.2013.07.020