Experience with immunomodulatory treatments in Rasmussen's encephalitis

Tiziana Granata, L. Fusco, G. Gobbi, E. Freri, F. Ragona, G. Broggi, R. Mantegazza, L. Giordano, F. Villani, G. Capovilla, F. Vigevano, B. Dalla Bernardina, R. Spreafico, C. Antozzi

Research output: Contribution to journalArticle

Abstract

The authors investigated immunomodulatory treatments in 15 patients with Rasmussen encephalitis (RE) (14 with childhood and one with adolescent onset RE). Positive time-limited responses were obtained in 11 patients using variable combinations of corticosteroids, apheresis, and high-dose IV immunoglobulins. Although surgical exclusion of the affected hemisphere is the only treatment that halts disease progression, immunomodulation can be considered when early surgery is not feasible, in late-onset patients with slower disease progression, and in the few cases of bilateral disease.

Original languageEnglish
Pages (from-to)1807-1810
Number of pages4
JournalNeurology
Volume61
Issue number12
Publication statusPublished - Dec 23 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Granata, T., Fusco, L., Gobbi, G., Freri, E., Ragona, F., Broggi, G., Mantegazza, R., Giordano, L., Villani, F., Capovilla, G., Vigevano, F., Bernardina, B. D., Spreafico, R., & Antozzi, C. (2003). Experience with immunomodulatory treatments in Rasmussen's encephalitis. Neurology, 61(12), 1807-1810.