Abstract
Eighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal α2a-Interferon. The usual single dosage was 54 × 106 U at weekly intervals for four times (eight times in responders): 10 h-istologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. α2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy.
Original language | English |
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Pages (from-to) | 467-473 |
Number of pages | 7 |
Journal | Oncology |
Volume | 49 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1992 |
Keywords
- Alpha-2a interferon
- Intraperitoneal treatment
- Ovarian epithelial cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology