Experience with intraperitoneal alpha-2a interferon

Ornella Nicoletto; Mario V. Fiorentino; Orazio Vinante; Angelo Prosperi; Flavio Tredese; Salvatore Tumolo; Giovanni P. Cima; Silvio Monfardini

doi:10.1159/000227094

Experience with intraperitoneal alpha-2a interferon

Ornella Nicoletto, Mario V. Fiorentino, Orazio Vinante, Angelo Prosperi, Flavio Tredese, Salvatore Tumolo, Giovanni P. Cima, Silvio Monfardini

Research output: Contribution to journal › Article › peer-review

Abstract

Eighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal α_2a-Interferon. The usual single dosage was 54 × 10⁶ U at weekly intervals for four times (eight times in responders): 10 h-istologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. α_2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy.

Original language	English
Pages (from-to)	467-473
Number of pages	7
Journal	Oncology
Volume	49
Issue number	6
DOIs	https://doi.org/10.1159/000227094
Publication status	Published - 1992

Keywords

Alpha-2a interferon
Intraperitoneal treatment
Ovarian epithelial cancer

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1159/000227094

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title = "Experience with intraperitoneal alpha-2a interferon",

abstract = "Eighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal α2a-Interferon. The usual single dosage was 54 × 106 U at weekly intervals for four times (eight times in responders): 10 h-istologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. α2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy.",

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AU - Nicoletto, Ornella

AU - Fiorentino, Mario V.

AU - Vinante, Orazio

AU - Prosperi, Angelo

AU - Tredese, Flavio

AU - Tumolo, Salvatore

AU - Cima, Giovanni P.

AU - Monfardini, Silvio

PY - 1992

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AB - Eighteen patients affected with epithelial ovarian cancer have been treated by intraperitoneal α2a-Interferon. The usual single dosage was 54 × 106 U at weekly intervals for four times (eight times in responders): 10 h-istologically confirmed complete remissions and 3 partial remissions have been obtained; the toxicity was represented by fever in the majority of the cases, by abdominal discomfort in some cases, and by a mild transitory neurological complication in 1 case. Seventeen of 18 patients were pretreated, and 11 of 18 had only cytologic and/or microscopic disease. α2a-Interferon has proven to be very effective and moderately toxic in microscopic peritoneal disease of ovarian epithelial cancer previously treated with extensive surgery and intravenous cytotoxic chemotherapy.

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KW - Intraperitoneal treatment

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Experience with intraperitoneal alpha-2a interferon

Abstract

Keywords

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