Experience with trabectedin + pegylated liposomal doxorubicin for recurrent platinum-sensitive ovarian cancer unsuited to platinum rechallenge

Nicoletta Colombo, Anne Claire Hardy-Bessard, Gabriella Ferrandina, Christian Marth, Ignacio Romero

Research output: Contribution to journalReview article

Abstract

Introduction: As most patients with ovarian cancer experience multiple remissions and relapses, oncologists must prepare ahead for long-term treatment. While platinum-based regimens are standard of care for platinum-sensitive recurrence, there are circumstances in which platinum rechallenge is not the best approach. These situations include patients with limited sensitivity to platinum; patients with residual toxicity from previous platinum therapy; and patients at risk of developing hypersensitivity reactions. An alternative regimen for these patients is the non-platinum combination of trabectedin + pegylated liposomal doxorubicin (PLD). Areas covered: In this review, case studies are presented to illustrate how careful strategic planning, in terms of therapeutic choices and optimal sequencing, can achieve good outcomes in difficult-to-treat patients. Expert commentary: Advantages with use of trabectedin + PLD in selected patients with platinum-sensitive recurrent ovarian cancer include additional time to recover from platinum-related toxicities, avoidance of hypersensitivity reactions, and the ‘sequence effect’ by which trabectedin may enhance response to next platinum and prolong survival.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalExpert Review of Anticancer Therapy
Volume16
DOIs
Publication statusPublished - Nov 30 2016

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Keywords

  • Carboplatin
  • hypersensitivity
  • pegylated liposomal doxorubicin
  • platinum sensitive
  • recurrent ovarian cancer
  • sequence effect
  • trabectedin

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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