Experimental and therapeutical effects of sulpiride on the gastric and duodenal ulcer

M. Bortolotti, A. Baruzzi, L. Barbara

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Sulpiride (N[1 ethyl 2 pyrrolidinyl methyl] 2 methoxy 5 sulfamoylbenzamide) represents a further improvement in these drugs, since, while having antidepressant, antipsychotic, antiemetic and uninhibiting properties, it does not produce any drowsiness nor does it provoke a peripheral block of the autonomic nervous system. These characteristics induced several research workers to carry out studies not only in psychiatry, but also in psychosomatic medicine, and in particular in the peptic ulcer. This research on the effect of sulpiride on the ulcer was divided into two separate parts: a clinical therapeutic study to examine the antiulcer effectiveness of the drug and an experimental study to investigate the mechanism of the drug action on the gastric function; the results in 33 patients with peptic ulcer are discussed.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalMedicina Psicosomatica
Issue number1
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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