Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping

F. Follis, K. Miller, O. U. Scremin, S. Pett, R. Kessler, T. Temes, J. A. Wernly

Research output: Contribution to journalArticle

Abstract

Background: As in the brain, recent evidence has suggested a defect in the microcirculation during the reperfusion period after spinal cord ischemia. This investigation was undertaken in order to delineate blood flow dynamics in the postischemic spinal cord of the rat. Methods:: Male Sprague-Dawley rats underwent cross-clamping of the aorta and subclavian arteries (XC) for 11 minutes, Spinal cord blood flow (SCBF) was measured by autoradiography in the gray and white matter of cervical (Ce), thoracic (Th) and lumbar (Lu) regions during XC, 1 h, 6 h and 24 h (XC n = 8, 1 h n = 9, 6 h n = 9, and 24 h n = 11, groups) after XC, Control groups underwent surgical manipulations and : SCBF measurement but no XC (Sham 1, n = 8), or clamping of the subclavian arteries only (Sham 2, n = 8). Results: In Ce cord, there was no difference between SCBF of 1 h, 6 h, 24 h and Sham 1, In Th cord, SCBF was reduced during XC (P <0.003 vs Sham 2), 1 h, 6 h (P <0.04 and P <0.01 vs. Sham 1). In Lu cord, SCBF was not detectable in XC, and depressed in 1 h (P <0.003) and 6 h (P <0.003), There was no difference between 24 h and Sham 1 in Ce, Th, and Lu cords, Conclusions: The study demonstrated a period of delayed postischemic hypoperfusion in-the White and gray matter of Th and Lu cord segments lasting 6 h after XC, The phenomenon may play an important role in the ultimate fate of neural elements with borderline viability after ischemic injury.

Original languageEnglish
Pages (from-to)202-207
Number of pages6
JournalCanadian Journal of Neurological Sciences
Volume22
Issue number3
Publication statusPublished - 1995

Fingerprint

Constriction
Spinal Cord
Fetal Blood
Subclavian Artery
Spinal Cord Ischemia
Lumbosacral Region
Microcirculation
Autoradiography
Reperfusion
Sprague Dawley Rats
Aorta
Thorax
Control Groups

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Follis, F., Miller, K., Scremin, O. U., Pett, S., Kessler, R., Temes, T., & Wernly, J. A. (1995). Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping. Canadian Journal of Neurological Sciences, 22(3), 202-207.

Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping. / Follis, F.; Miller, K.; Scremin, O. U.; Pett, S.; Kessler, R.; Temes, T.; Wernly, J. A.

In: Canadian Journal of Neurological Sciences, Vol. 22, No. 3, 1995, p. 202-207.

Research output: Contribution to journalArticle

Follis, F, Miller, K, Scremin, OU, Pett, S, Kessler, R, Temes, T & Wernly, JA 1995, 'Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping', Canadian Journal of Neurological Sciences, vol. 22, no. 3, pp. 202-207.
Follis, F. ; Miller, K. ; Scremin, O. U. ; Pett, S. ; Kessler, R. ; Temes, T. ; Wernly, J. A. / Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping. In: Canadian Journal of Neurological Sciences. 1995 ; Vol. 22, No. 3. pp. 202-207.
@article{b2824d7227494a34ae5df9230734cbc6,
title = "Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping",
abstract = "Background: As in the brain, recent evidence has suggested a defect in the microcirculation during the reperfusion period after spinal cord ischemia. This investigation was undertaken in order to delineate blood flow dynamics in the postischemic spinal cord of the rat. Methods:: Male Sprague-Dawley rats underwent cross-clamping of the aorta and subclavian arteries (XC) for 11 minutes, Spinal cord blood flow (SCBF) was measured by autoradiography in the gray and white matter of cervical (Ce), thoracic (Th) and lumbar (Lu) regions during XC, 1 h, 6 h and 24 h (XC n = 8, 1 h n = 9, 6 h n = 9, and 24 h n = 11, groups) after XC, Control groups underwent surgical manipulations and : SCBF measurement but no XC (Sham 1, n = 8), or clamping of the subclavian arteries only (Sham 2, n = 8). Results: In Ce cord, there was no difference between SCBF of 1 h, 6 h, 24 h and Sham 1, In Th cord, SCBF was reduced during XC (P <0.003 vs Sham 2), 1 h, 6 h (P <0.04 and P <0.01 vs. Sham 1). In Lu cord, SCBF was not detectable in XC, and depressed in 1 h (P <0.003) and 6 h (P <0.003), There was no difference between 24 h and Sham 1 in Ce, Th, and Lu cords, Conclusions: The study demonstrated a period of delayed postischemic hypoperfusion in-the White and gray matter of Th and Lu cord segments lasting 6 h after XC, The phenomenon may play an important role in the ultimate fate of neural elements with borderline viability after ischemic injury.",
author = "F. Follis and K. Miller and Scremin, {O. U.} and S. Pett and R. Kessler and T. Temes and Wernly, {J. A.}",
year = "1995",
language = "English",
volume = "22",
pages = "202--207",
journal = "Canadian Journal of Neurological Sciences",
issn = "0317-1671",
publisher = "Canadian Journal of Neurological Sciences",
number = "3",

}

TY - JOUR

T1 - Experimental delayed postischemic spinal cord hypoperfusion after aortic cross-clamping

AU - Follis, F.

AU - Miller, K.

AU - Scremin, O. U.

AU - Pett, S.

AU - Kessler, R.

AU - Temes, T.

AU - Wernly, J. A.

PY - 1995

Y1 - 1995

N2 - Background: As in the brain, recent evidence has suggested a defect in the microcirculation during the reperfusion period after spinal cord ischemia. This investigation was undertaken in order to delineate blood flow dynamics in the postischemic spinal cord of the rat. Methods:: Male Sprague-Dawley rats underwent cross-clamping of the aorta and subclavian arteries (XC) for 11 minutes, Spinal cord blood flow (SCBF) was measured by autoradiography in the gray and white matter of cervical (Ce), thoracic (Th) and lumbar (Lu) regions during XC, 1 h, 6 h and 24 h (XC n = 8, 1 h n = 9, 6 h n = 9, and 24 h n = 11, groups) after XC, Control groups underwent surgical manipulations and : SCBF measurement but no XC (Sham 1, n = 8), or clamping of the subclavian arteries only (Sham 2, n = 8). Results: In Ce cord, there was no difference between SCBF of 1 h, 6 h, 24 h and Sham 1, In Th cord, SCBF was reduced during XC (P <0.003 vs Sham 2), 1 h, 6 h (P <0.04 and P <0.01 vs. Sham 1). In Lu cord, SCBF was not detectable in XC, and depressed in 1 h (P <0.003) and 6 h (P <0.003), There was no difference between 24 h and Sham 1 in Ce, Th, and Lu cords, Conclusions: The study demonstrated a period of delayed postischemic hypoperfusion in-the White and gray matter of Th and Lu cord segments lasting 6 h after XC, The phenomenon may play an important role in the ultimate fate of neural elements with borderline viability after ischemic injury.

AB - Background: As in the brain, recent evidence has suggested a defect in the microcirculation during the reperfusion period after spinal cord ischemia. This investigation was undertaken in order to delineate blood flow dynamics in the postischemic spinal cord of the rat. Methods:: Male Sprague-Dawley rats underwent cross-clamping of the aorta and subclavian arteries (XC) for 11 minutes, Spinal cord blood flow (SCBF) was measured by autoradiography in the gray and white matter of cervical (Ce), thoracic (Th) and lumbar (Lu) regions during XC, 1 h, 6 h and 24 h (XC n = 8, 1 h n = 9, 6 h n = 9, and 24 h n = 11, groups) after XC, Control groups underwent surgical manipulations and : SCBF measurement but no XC (Sham 1, n = 8), or clamping of the subclavian arteries only (Sham 2, n = 8). Results: In Ce cord, there was no difference between SCBF of 1 h, 6 h, 24 h and Sham 1, In Th cord, SCBF was reduced during XC (P <0.003 vs Sham 2), 1 h, 6 h (P <0.04 and P <0.01 vs. Sham 1). In Lu cord, SCBF was not detectable in XC, and depressed in 1 h (P <0.003) and 6 h (P <0.003), There was no difference between 24 h and Sham 1 in Ce, Th, and Lu cords, Conclusions: The study demonstrated a period of delayed postischemic hypoperfusion in-the White and gray matter of Th and Lu cord segments lasting 6 h after XC, The phenomenon may play an important role in the ultimate fate of neural elements with borderline viability after ischemic injury.

UR - http://www.scopus.com/inward/record.url?scp=0029113111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029113111&partnerID=8YFLogxK

M3 - Article

C2 - 8529172

AN - SCOPUS:0029113111

VL - 22

SP - 202

EP - 207

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

SN - 0317-1671

IS - 3

ER -