Abstract
The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.
| Original language | English |
|---|---|
| Pages (from-to) | 1253-1257 |
| Number of pages | 5 |
| Journal | European Heart Journal |
| Volume | 14 |
| Issue number | 9 |
| Publication status | Published - 1993 |
Fingerprint
Keywords
- Antiarrhythmic drugs
- Beta-adrenergic blockade
- Propafenone
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Physiology
Cite this
Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance. / Malfatto, G.; Pessano, P.; Zaza, A.; Schwartz, P. J.
In: European Heart Journal, Vol. 14, No. 9, 1993, p. 1253-1257.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance
AU - Malfatto, G.
AU - Pessano, P.
AU - Zaza, A.
AU - Schwartz, P. J.
PY - 1993
Y1 - 1993
N2 - The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.
AB - The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.
KW - Antiarrhythmic drugs
KW - Beta-adrenergic blockade
KW - Propafenone
UR - http://www.scopus.com/inward/record.url?scp=0027381382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027381382&partnerID=8YFLogxK
M3 - Article
C2 - 7901020
AN - SCOPUS:0027381382
VL - 14
SP - 1253
EP - 1257
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 9
ER -