Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance

G. Malfatto, P. Pessano, A. Zaza, P. J. Schwartz

Research output: Contribution to journalArticle

Abstract

The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.

Original languageEnglish
Pages (from-to)1253-1257
Number of pages5
JournalEuropean Heart Journal
Volume14
Issue number9
Publication statusPublished - 1993

Fingerprint

Propafenone
Heart Rate
Adrenergic Agents
Myocardial Ischemia
Sodium Channel Blockers
Flecainide
Stellate Ganglion
Nerve
Propranolol
Ganglia
Sodium
Acute
Cardiac
Decentralized
Reflex
Activation
Cats
Chemical activation
Relevance
Evidence

Keywords

  • Antiarrhythmic drugs
  • Beta-adrenergic blockade
  • Propafenone

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance. / Malfatto, G.; Pessano, P.; Zaza, A.; Schwartz, P. J.

In: European Heart Journal, Vol. 14, No. 9, 1993, p. 1253-1257.

Research output: Contribution to journalArticle

@article{d056943ef280470f9d4aa2108e9c478d,
title = "Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance",
abstract = "The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.",
keywords = "Antiarrhythmic drugs, Beta-adrenergic blockade, Propafenone",
author = "G. Malfatto and P. Pessano and A. Zaza and Schwartz, {P. J.}",
year = "1993",
language = "English",
volume = "14",
pages = "1253--1257",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Experimental evidence for beta adrenergic blocking properties of propafenone and for their potential clinical relevance

AU - Malfatto, G.

AU - Pessano, P.

AU - Zaza, A.

AU - Schwartz, P. J.

PY - 1993

Y1 - 1993

N2 - The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.

AB - The magnitude and biological relevance in vivo of the beta-blocking properties, observed in vitro, of propafenone remains controversial. We studied the effects of propafenone on the heart rate response to graded stimulation of the right stellate ganglion in 13 anaesthetized, vagotomized cats. The decentralized ganglion was stimulated (3 ms, 10 to 15 V) for periods of 45 s at frequencies from 1 to 14 Hz. The effects of sympathetic stimulation on heart rate were evaluated by the relationship between stimulation frequency and changes in heart rate from control. The relationship was significantly displaced downward and to the right by propafenone (4 mg . kg,-1 n = 7), indicating a blunted response to sympathetic stimulation. This effect was lost at the highest frequencies. The frequency range at which propafenone was effective is the same as that elicited in cardiac sympathetic nerves by acute myocardial ischaemia. With propranolol (0.5 mg . kg-1 n=4), the effects on the heart rate response were similar but of greater magnitude. Another sodium channel blocker (flecainide, 4 mg . kg-1 n=2) was administered, and no changes were observed in the heart rate response. Thus, propafenone has significant beta-blocking effects, which would be of clinical relevance during the reflex sympathetic activation consequent to myocardial ischaemia.

KW - Antiarrhythmic drugs

KW - Beta-adrenergic blockade

KW - Propafenone

UR - http://www.scopus.com/inward/record.url?scp=0027381382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027381382&partnerID=8YFLogxK

M3 - Article

C2 - 7901020

AN - SCOPUS:0027381382

VL - 14

SP - 1253

EP - 1257

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 9

ER -