Experimental hypothyroidism modulates the expression of the low density lipoprotein receptor by the liver

Lia Scarabottolo, Ermanno Trezzi, Paola Roma, Alberico L. Catapano

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of experimental hypothyroidism on the catabolism of plasma lipoproteins and on the expression of low density lipoprotein receptors by the liver was investigated in rats made hypothyroid by surgery. The animals developed mild hypercholesterolemia, mainly due to an increase of plasma low density lipoprotein, while other lipoprotein classes were only marginally affected. Kinetic studies using [125I]LDL indicated that a decreased fractional catabolic rate of the lipoprotein was responsible for this finding in agreement with the in vitro observation of a reduced binding of lipoproteins to liver membranes from hypothyroid rats and with the demonstration, by ligand blotting analysis, of a decreased expression of lipoprotein receptors in liver membranes. These data suggest that hypothyroidism affects lipoprotein distribution also by decreasing the catabolism of low density lipoproteins by the liver.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalAtherosclerosis
Volume59
Issue number3
DOIs
Publication statusPublished - 1986

Keywords

  • Hypercholesterolemia
  • Hypothyroidism
  • LDL receptors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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