Emodiluizione isovolemica sperimentale. Studio sulla perfusione tessutale ad Hb 3 g% nel suino.

Translated title of the contribution: Experimental isovolemic hemodilution. Study of tissue perfusion with Hb 3% in swine

S. Faenza, R. Fato, S. Lari, G. Lenaz, N. Maraldi, F. Pallotti, S. Perin, P. Sabatelli, C. Uguccioni, A. Zanoni, A. Zanoni

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The aim of the study is to evaluate the limits of the compensatory mechanisms and the tissue damages caused by the low oxygen content during severe normovolemic hemodilution in pigs. METHODS: The experimental procedure was performed in 10 animals after general anaesthesia was induced and iso-hypervolemic hemodilution to Hct 10% was maintained for five hours without any intensive care. Hemodynamic, biochemical and ultrastructural parameters were detected before and at the end of hemodilution in addition to analysis of oxygen delivery/uptake and mitochondrial enzymes function. RESULTS: The collected data show: the initial good compensatory mechanism was subsequently exhausted; five animals demonstrated cardiac ischemia and low CO and two of them died before the end of the experiment; no hemodynamic and hemoxymetric data predicted the cardiac ischemia; the dilution caused alterations of some detected biochemical parameters such as hemocoagulation; no evidence of morphologic and ultrastructural tissue damage or interstitial edema; decreasing in mitochondrial enzymes activity significant only for NADH-related. CONCLUSIONS: In conclusion, it seems that, in pigs at least, the compensatory mechanisms can keep a sufficient tissue oxygen supply throughout the experimental time with the exception of cardiac muscle.

Translated title of the contributionExperimental isovolemic hemodilution. Study of tissue perfusion with Hb 3% in swine
Original languageItalian
Pages (from-to)229-236
Number of pages8
JournalMinerva Anestesiologica
Issue number7-8
Publication statusPublished - Jul 1997

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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