Experimental model for pharmacokinetic studies during continuous peritoneal dialysis in the rabbit

Gian Luigi Traina, Antonio Celardo, Margarita Arboix, Maurizio Bonati

Research output: Contribution to journalArticle

Abstract

An experimental model permitting continuous peritoneal dialysis in rabbits, very close to continuous ambulatory peritoneal dialysis (CAPD) as performed in humans, is described. Animals were carefully monitored before and during dialysis for plasma, urine and dialysate biochemical parameters, and electrocardiogram, body temperature, weight, and white cell count in dialysate. Dialysis was performed successfully for 21 days without failure. Difficulties in setting up the final model are reported. The suitability of the model for pharmacokinetic and pharmacodynamic studies was borne out by administering atenolol (i.v. before CADP, i.v. after one week of CAPD, and i.p. one week later) and analyzing the findings.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalJournal of Pharmacological Methods
Volume15
Issue number2
DOIs
Publication statusPublished - 1986

Keywords

  • Atenolol
  • Continuous ambulatory peritoneal dialysis
  • Pharmacodynamics
  • Pharmacokinetics
  • Rabbit

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Experimental model for pharmacokinetic studies during continuous peritoneal dialysis in the rabbit'. Together they form a unique fingerprint.

  • Cite this