Experimental Models for the Study of Female and Male Sexual Function

Francois Giuliano, James Pfaus, Srilatha Balasubramanian, Petter Hedlund, Shin ichi Hisasue, Lesley Marson, Kim Wallen

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Introduction: Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim: To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods: Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure: Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results: Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions: Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995.

Original languageEnglish
Pages (from-to)2970-2995
Number of pages26
JournalJournal of Sexual Medicine
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Theoretical Models
Animal Models
Research
Pharmacology
Arousal
Documentation
Nervous System
Blood Vessels
Consensus
Outcome Assessment (Health Care)
Therapeutics

Keywords

  • Animal models
  • Behavioral studies
  • Female sexual function
  • In vitro studies
  • In vivo studies
  • Male sexual function

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Giuliano, F., Pfaus, J., Balasubramanian, S., Hedlund, P., Hisasue, S. I., Marson, L., & Wallen, K. (2010). Experimental Models for the Study of Female and Male Sexual Function. Journal of Sexual Medicine, 7(9), 2970-2995. https://doi.org/10.1111/j.1743-6109.2010.01960.x

Experimental Models for the Study of Female and Male Sexual Function. / Giuliano, Francois; Pfaus, James; Balasubramanian, Srilatha; Hedlund, Petter; Hisasue, Shin ichi; Marson, Lesley; Wallen, Kim.

In: Journal of Sexual Medicine, Vol. 7, No. 9, 09.2010, p. 2970-2995.

Research output: Contribution to journalArticle

Giuliano, F, Pfaus, J, Balasubramanian, S, Hedlund, P, Hisasue, SI, Marson, L & Wallen, K 2010, 'Experimental Models for the Study of Female and Male Sexual Function', Journal of Sexual Medicine, vol. 7, no. 9, pp. 2970-2995. https://doi.org/10.1111/j.1743-6109.2010.01960.x
Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue SI, Marson L et al. Experimental Models for the Study of Female and Male Sexual Function. Journal of Sexual Medicine. 2010 Sep;7(9):2970-2995. https://doi.org/10.1111/j.1743-6109.2010.01960.x
Giuliano, Francois ; Pfaus, James ; Balasubramanian, Srilatha ; Hedlund, Petter ; Hisasue, Shin ichi ; Marson, Lesley ; Wallen, Kim. / Experimental Models for the Study of Female and Male Sexual Function. In: Journal of Sexual Medicine. 2010 ; Vol. 7, No. 9. pp. 2970-2995.
@article{85ec67fa89764733b34b1d524058744f,
title = "Experimental Models for the Study of Female and Male Sexual Function",
abstract = "Introduction: Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim: To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods: Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure: Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results: Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions: Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995.",
keywords = "Animal models, Behavioral studies, Female sexual function, In vitro studies, In vivo studies, Male sexual function",
author = "Francois Giuliano and James Pfaus and Srilatha Balasubramanian and Petter Hedlund and Hisasue, {Shin ichi} and Lesley Marson and Kim Wallen",
year = "2010",
month = "9",
doi = "10.1111/j.1743-6109.2010.01960.x",
language = "English",
volume = "7",
pages = "2970--2995",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Experimental Models for the Study of Female and Male Sexual Function

AU - Giuliano, Francois

AU - Pfaus, James

AU - Balasubramanian, Srilatha

AU - Hedlund, Petter

AU - Hisasue, Shin ichi

AU - Marson, Lesley

AU - Wallen, Kim

PY - 2010/9

Y1 - 2010/9

N2 - Introduction: Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim: To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods: Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure: Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results: Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions: Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995.

AB - Introduction: Significant progress has been made in the understanding of physiological and pharmacological mechanisms of human sexual functioning through preclinical research in animal models. Aim: To provide an evidence-based documentation of the experimental models evaluating male and female sexual function for useful clinical translation. Methods: Consensus discussion over the past 18 months leading to summarized views of seven experts from six countries. Main Outcome Measure: Report was based on the critical analysis of scientific information available in literature and subcommittee presentations, discussions, and exchanges of ideas and feedback. Results: Fundamental research in animal models has led to considerable understanding of the physiological mechanisms underlying desire, arousal, genital, and other sexual responses and the design of rational pharmacological treatments for certain sexual dysfunctions in the male and female. Tissue and cellular in vitro systems have provided critical information on the in vivo interactions and modulations in the presence and absence of chemical, biological, vascular, neurologic, endocrine, and genetic inputs. The animal models seem indispensable for elucidating the biophysiological and etiopathological aspects of male and female sexual disorders. Conclusions: Useful insights into the human experience have been derived from basic research in ways that are far more difficult to obtain in humans, both scientifically and ethically. The animal model with a good predictive value can be used as a successful preclinical tool so long as the functional end points are homologous or analogous. The key issue is whether further evaluations are warranted to extrapolate the results in a clinical setting. Giuliano F, Pfaus J, Balasubramanian S, Hedlund P, Hisasue S, Marson L, and Wallen K. Experimental models for the study of female and male sexual function. J Sex Med 2010;7:2970-2995.

KW - Animal models

KW - Behavioral studies

KW - Female sexual function

KW - In vitro studies

KW - In vivo studies

KW - Male sexual function

UR - http://www.scopus.com/inward/record.url?scp=77956295224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956295224&partnerID=8YFLogxK

U2 - 10.1111/j.1743-6109.2010.01960.x

DO - 10.1111/j.1743-6109.2010.01960.x

M3 - Article

VL - 7

SP - 2970

EP - 2995

JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

IS - 9

ER -