Experimental models of glioma

Paolo Malatesta, Filippo Calzolari, Irene Appolloni

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The development and refinement of animal models of gliomagenesis has been fundamental to test hypotheses concerning the etiology of gliomas and their molecular and cellular pathogenesis. During the last few decades, modeling has gained in complexity and is nowadays mostly relying on the cell type-specific modulation of the expression of candidate oncogenes and oncosuppressors. Despite such technological advances, the recent appreciation of the molecular heterogeneity underlying human high-grade glioma variability revealed the need for a deeper characterization of the available models. It is now clear that most of the existing animal systems mimic one of the human molecular classes, known as proneural, leaving the other groups underrepresented. While there is thus the need for an expansion of the range of available models, existing ones have already proven useful as translational research platforms, allowing preliminary assessment of the efficacy of classical and innovative therapeutic approaches. In this contribution, we provide a general view of the field and synthesize our understanding of the biology of the most thoroughly studied model family, that of platelet-derived growth factor (PDGF)-induced gliomas.

Original languageEnglish
Title of host publicationGlioma Cell Biology
PublisherSpringer-Verlag Wien
Pages399-431
Number of pages33
ISBN (Print)9783709114315, 3709114306, 9783709114308
DOIs
Publication statusPublished - Sep 1 2012

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Keywords

  • Glioma
  • Neural stem cells
  • Oncogene
  • Orthotopic transplant
  • Retrovirus
  • RTK signaling
  • Tumor suppressor

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Malatesta, P., Calzolari, F., & Appolloni, I. (2012). Experimental models of glioma. In Glioma Cell Biology (pp. 399-431). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1431-5_13