OSTEOPOROSI SPERIMENTALE DA CARENZA ETROGENICA NEL RATTO. RUOLO DELL'ASSOCIAZIONE LATTOSIO, L-ARGININA, L-LISINA NELLA PREVENZIONE E TERAPIA

Translated title of the contribution: Experimental osteoporosis from estrogenic deficiency in the rat: Role of the lactose, L-arginine and L-lysine association in prevention and treatment

M. Fini, R. Giardino, R. Mongiorgi, G. Cantelli Forti, S. Gnudi, N. Nicoli Aldini, C. Valdrè, D. Piotti, G. Giavaresi, L. Orienti, M. Rocca, A. Sapone, A. Rossetti

Research output: Contribution to journalArticle

Abstract

The role of a lactose, L-arginine and L-lysine association in the treatment of osteoporosis was evaluated in an in vivo model. Fifty Sprague Dawley female rats, 10 months age, were divided into 5 groups: 10 non-ovariectomized animals sacrificed at the beginning of the study (I group); 10 ovariectomized animals (OVX) without treatment and sacrificed at three months (II group); 10 OVX animals without treatment sacrificed at 6 months; 10 OVX animals treated starting from the I postoperative day with the association for three months (IV group, prevention) and 10 OVX animals treated like those of the IV group starting three months after surgery (V group, therapy). Animals were sacrificed in general anesthesia according to the scheduled times for radiologic, densitometric, histologic and mineralogic investigations. Preliminary results, which will need further researches, seem to show a progressive reduction of bone mass after ovariectomy in 10 months female rat and that the pharmacological association given as therapy (V group) may be able to lessen the reduction of bone mineral content.

Original languageItalian
Pages (from-to)81-88
Number of pages8
JournalMinerva Medica
Volume87
Issue number3
Publication statusPublished - Mar 1996

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fini, M., Giardino, R., Mongiorgi, R., Forti, G. C., Gnudi, S., Aldini, N. N., Valdrè, C., Piotti, D., Giavaresi, G., Orienti, L., Rocca, M., Sapone, A., & Rossetti, A. (1996). OSTEOPOROSI SPERIMENTALE DA CARENZA ETROGENICA NEL RATTO. RUOLO DELL'ASSOCIAZIONE LATTOSIO, L-ARGININA, L-LISINA NELLA PREVENZIONE E TERAPIA. Minerva Medica, 87(3), 81-88.