Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum

Maddalena Napolitano, Diego Centonze, Angelica Calce, Barbara Picconi, Stefania Spiezia, Alberto Gulino, Giorgio Bernardi, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

The irreversible loss of the dopamine-mediated control of striatal function is considered the functional substrate of the motor symptoms of Parkinson's disease. This pathological event causes a complex rearrangement of neuronal activity which involves specific dopamine-regulated cellular functions and, secondarily, several other cellular properties and transmitter systems. In the present study, we applied recently developed cDNA microarray technology to investigate the genetic correlates of the alterations produced by 6-hydroxydopamine-induced dopamine denervation in the nucleus striatum. We found that chronic dopamine denervation caused the modulation of 50 different genes involved in several cellular functions. In particular, products of the genes modulated by this experimental manipulation are involved both in the intracellular transduction of dopamine signal and in the regulation of glutamate transmission in striatal neurons, providing some information on the possible neuronal events which lead to the reorganization of glutamate transmission in the striatum of parkinsonian rats.

Original languageEnglish
Pages (from-to)387-395
Number of pages9
JournalNeurobiology of Disease
Volume10
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • 6-hydroxydopamine
  • Basal ganglia
  • cDNA microarrays
  • Glutamate transmission
  • Parkinson's disease
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neurology

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