TY - JOUR
T1 - Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum
AU - Napolitano, Maddalena
AU - Centonze, Diego
AU - Calce, Angelica
AU - Picconi, Barbara
AU - Spiezia, Stefania
AU - Gulino, Alberto
AU - Bernardi, Giorgio
AU - Calabresi, Paolo
PY - 2002
Y1 - 2002
N2 - The irreversible loss of the dopamine-mediated control of striatal function is considered the functional substrate of the motor symptoms of Parkinson's disease. This pathological event causes a complex rearrangement of neuronal activity which involves specific dopamine-regulated cellular functions and, secondarily, several other cellular properties and transmitter systems. In the present study, we applied recently developed cDNA microarray technology to investigate the genetic correlates of the alterations produced by 6-hydroxydopamine-induced dopamine denervation in the nucleus striatum. We found that chronic dopamine denervation caused the modulation of 50 different genes involved in several cellular functions. In particular, products of the genes modulated by this experimental manipulation are involved both in the intracellular transduction of dopamine signal and in the regulation of glutamate transmission in striatal neurons, providing some information on the possible neuronal events which lead to the reorganization of glutamate transmission in the striatum of parkinsonian rats.
AB - The irreversible loss of the dopamine-mediated control of striatal function is considered the functional substrate of the motor symptoms of Parkinson's disease. This pathological event causes a complex rearrangement of neuronal activity which involves specific dopamine-regulated cellular functions and, secondarily, several other cellular properties and transmitter systems. In the present study, we applied recently developed cDNA microarray technology to investigate the genetic correlates of the alterations produced by 6-hydroxydopamine-induced dopamine denervation in the nucleus striatum. We found that chronic dopamine denervation caused the modulation of 50 different genes involved in several cellular functions. In particular, products of the genes modulated by this experimental manipulation are involved both in the intracellular transduction of dopamine signal and in the regulation of glutamate transmission in striatal neurons, providing some information on the possible neuronal events which lead to the reorganization of glutamate transmission in the striatum of parkinsonian rats.
KW - 6-hydroxydopamine
KW - Basal ganglia
KW - cDNA microarrays
KW - Glutamate transmission
KW - Parkinson's disease
KW - Synaptic plasticity
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U2 - 10.1006/nbdi.2002.0525
DO - 10.1006/nbdi.2002.0525
M3 - Article
C2 - 12270699
AN - SCOPUS:0036408413
VL - 10
SP - 387
EP - 395
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
IS - 3
ER -