Experimental wound dressing by heterologous collagen: A morphological-quantitative approach

M. Mattioli Belmonte, G. Biagini, G. Ricotti, C. Zucchini, C. Castaldini, M. Fini, R. Giardino, M. Bigini

Research output: Contribution to journalArticlepeer-review


The use of heterologous collagen in skin repair processes has proved to be an efficacious approach for the reconstitution of injured tissue. A morphological and quantitative evaluation of the reactive and reparative capacity of injured tissue treated either with conventional medications or with heterologous collagen (Condress) in the form of sponges was carried out. We have analyzed experimental surgical lesions on an animal model and evaluated the repair processes of the lesions, including the excision of the cutaneous and subcutaneous tissue. The heterologous collagen sponges provided biological support to obtain healed skin of better quality. Tissue lesions healed more rapidly, thus reducing the risk of recurrence. This experimental study provides morphological and structural data for further investigation.

Original languageEnglish
Pages (from-to)365-382
Number of pages18
JournalJournal of Bioactive and Compatible Polymers
Issue number4
Publication statusPublished - Oct 1993

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics


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