Expert consensus on palivizumab use for respiratory syncytial virus in developed countries

Manuel Sánchez Luna, Paolo Manzoni, Bosco Paes, Eugenio Baraldi, Veerle Cossey, Amir Kugelman, Rupesh Chawla, Andrea Dotta, Rosa Rodríguez Fernández, Bernhard Resch, Xavier Carbonell-Estrany

Research output: Contribution to journalReview articlepeer-review

Abstract

Respiratory syncytial virus (RSV) infection is a leading cause of hospitalisation in early childhood and palivizumab is the only licensed intervention for prevention. Palivizumab guidelines should reflect the latest evidence, in addition to cost-effectiveness and healthcare budgetary considerations. RSV experts from Europe, Canada and Israel undertook a systematic review of the evidence over the last 5 years and developed recommendations regarding prophylaxis in industrialised countries. Almost 400 publications were reviewed. This group recommended palivizumab for: preterm infants (<29 and ≤31 weeks gestational age [wGA] and ≤9 and ≤6 months of age, respectively; high-risk 32-35wGA), former preterm children ≤24 months with chronic lung disease/bronchopulmonary dysplasia, children ≤24 months with significant congenital heart disease; and other high-risk populations, such as children ≤24 months with Down syndrome, pulmonary/neuromuscular disorders, immunocompromised, and cystic fibrosis. Up to 5 monthly doses should be administered over the RSV season. It is our impression that the adoption of these guidelines would help reduce the burden of RSV.

Original languageEnglish
JournalPaediatric Respiratory Reviews
DOIs
Publication statusPublished - 2019

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