Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo

M. Tiziana Corasaniti, Mauro Maccarrone, Robert Nistico, Walter Malorni, Domenicantonio Rotiroti, Giacinto Bagetta

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Neuronal loss has often been described at post-mortem in the brain neocortex of patients suffering from AIDS. Neuro-invasive strains of HIV infect macrophages, microglial cells and multinucleated giant cells, but not neurones. Processing of the virus by cells of the myelomonocytic lineage yields viral products that, in conjunction with potentially neurotoxic molecules generated by the host, might initiate a complex network of events which lead neurones to death. In particular, the HIV-1 coat glycoprotein, gp120, has been proposed as a likely aetiologic agent of the described neuronal loss because it causes death of neurones in culture. More recently, it has been shown that brain neocortical cell death is caused in rat by intracerebroventricular injection of a recombinant gp120 coat protein, and that this occurs via apoptosis. The latter observation broadens our knowledge in the pathophysiology of the reported neuronal cell loss and opens a new lane of experimental research for the development of novel therapeutic strategies to limit damage to the brain of patients suffering from HIV-associated dementia.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Neurochemistry
Volume79
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Neurons
HIV-1
Brain
Glycoproteins
AIDS Dementia Complex
Macrophages
Neocortex
Complex networks
Capsid Proteins
Cell Lineage
Cell death
Giant Cells
Viruses
Rats
Cause of Death
Acquired Immunodeficiency Syndrome
Cell Death
Observation
HIV
Apoptosis

Keywords

  • Apoptosis
  • Cyclooxygenase type-2 (COX-2)
  • HIV-1 gp120
  • HIV-associated dementia (HAD)
  • Interleukin-1β
  • Neocortex

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo. / Corasaniti, M. Tiziana; Maccarrone, Mauro; Nistico, Robert; Malorni, Walter; Rotiroti, Domenicantonio; Bagetta, Giacinto.

In: Journal of Neurochemistry, Vol. 79, No. 1, 2001, p. 1-8.

Research output: Contribution to journalArticle

Corasaniti, M. Tiziana ; Maccarrone, Mauro ; Nistico, Robert ; Malorni, Walter ; Rotiroti, Domenicantonio ; Bagetta, Giacinto. / Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo. In: Journal of Neurochemistry. 2001 ; Vol. 79, No. 1. pp. 1-8.
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