Exploration of the early insulin response by two small successive loads of I.V. glucose in normal and obese subjects

Romano Prando, Renzo Cordera, Patrizio Odetti, Alberto De Micheli, Michele Maiello, Giorgio Viviani, Luciano Adezati

Research output: Contribution to journalArticle

Abstract

Two 5 g glucose loads at 1-h interval were given to healthy controls and obese subjects with slightly altered or normal OGTT in order to explore the capacity of restoration of the 'rapid insulin response' to i.v. glucose. In the normal subjects, the two successive loads gave rise to identical responses as far as maximum increase (Δmax), average increase at 2-5 min (Δ2-5 min), area of increase 0-15 min (Δ0-15 min) for both glucose and IRI, were concerned. Obese subjects could be divided on the basis of their insulin response to the first load into normal responders (group I) and high-responders (group II). In group I obese subjects, the responses to the second load were identical to those to the first. In group II obese subjects Δmax, Δ2-5 min and Δ0-15 min of the insulin response to the second load were reduced as compared to the first.

Original languageEnglish
Pages (from-to)53-67
Number of pages15
JournalActa Diabetologica Latina
Volume15
Issue number1-2
DOIs
Publication statusPublished - Jan 1978

Keywords

  • Early insulin response
  • Glucose
  • IRI
  • NEFA
  • Obesity
  • Successive loads

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Prando, R., Cordera, R., Odetti, P., De Micheli, A., Maiello, M., Viviani, G., & Adezati, L. (1978). Exploration of the early insulin response by two small successive loads of I.V. glucose in normal and obese subjects. Acta Diabetologica Latina, 15(1-2), 53-67. https://doi.org/10.1007/BF02581007