Exploration of therapeutic targets for sexual dysfunctions: Lessons learned from the failed stories

Ibrahim A. Abdel-Hamid, Karl Erik Andersson, Andrea Salonia

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: The ratio between research and successful targets in a disease class gives a good indication about the extent of the exploration of additional targets for diseases in that class. This ratio is still very low for the field of sexual medicine. 'Failures' in drug development can be highly instructive, but are not often addressed. Areas covered: We performed a review of the literature based on published data on four failure stories including targeting adrenergic receptors for erectile dysfunction (ED), targeting dopamine receptors by apomorphine for ED, serotonergic transporters as a target for premature ejaculation and PDE5 as a target for female sexual dysfunctions. The search included: i) a MEDLINE search from 1966 through November 2010 limited to English language medical literature, ii) relevant abstracts from 2009 and 2010 and iii) a pipeline search for therapeutics in development. The aim is to inform readers about the lessons learned from four selected failed therapeutic stories during therapeutic target exploration for sexual dysfunctions. Expert opinion: By learning from failures, a drug may not only be kept alive, but also better therapeutic strategies and design of new drugs may be developed.

Original languageEnglish
Pages (from-to)325-340
Number of pages16
JournalExpert Opinion on Therapeutic Targets
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Erectile Dysfunction
Pharmaceutical Preparations
Apomorphine
Dopamine Receptors
Premature Ejaculation
Adrenergic Receptors
Medicine
Drug Design
Expert Testimony
Therapeutics
Pipelines
MEDLINE
Language
Learning
Research

Keywords

  • Adrenergic receptors
  • Dopamine receptors
  • Erectile dysfunction
  • Female sexual dysfunctions
  • Lessons learned
  • PDE5 enzymes
  • Premature ejaculation
  • Serotonergic transporters
  • Sexual dysfunctions
  • Therapeutic targets

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Exploration of therapeutic targets for sexual dysfunctions : Lessons learned from the failed stories. / Abdel-Hamid, Ibrahim A.; Andersson, Karl Erik; Salonia, Andrea.

In: Expert Opinion on Therapeutic Targets, Vol. 15, No. 3, 03.2011, p. 325-340.

Research output: Contribution to journalArticle

@article{2226dd4700924c35a32dbeb46a6ff57f,
title = "Exploration of therapeutic targets for sexual dysfunctions: Lessons learned from the failed stories",
abstract = "Introduction: The ratio between research and successful targets in a disease class gives a good indication about the extent of the exploration of additional targets for diseases in that class. This ratio is still very low for the field of sexual medicine. 'Failures' in drug development can be highly instructive, but are not often addressed. Areas covered: We performed a review of the literature based on published data on four failure stories including targeting adrenergic receptors for erectile dysfunction (ED), targeting dopamine receptors by apomorphine for ED, serotonergic transporters as a target for premature ejaculation and PDE5 as a target for female sexual dysfunctions. The search included: i) a MEDLINE search from 1966 through November 2010 limited to English language medical literature, ii) relevant abstracts from 2009 and 2010 and iii) a pipeline search for therapeutics in development. The aim is to inform readers about the lessons learned from four selected failed therapeutic stories during therapeutic target exploration for sexual dysfunctions. Expert opinion: By learning from failures, a drug may not only be kept alive, but also better therapeutic strategies and design of new drugs may be developed.",
keywords = "Adrenergic receptors, Dopamine receptors, Erectile dysfunction, Female sexual dysfunctions, Lessons learned, PDE5 enzymes, Premature ejaculation, Serotonergic transporters, Sexual dysfunctions, Therapeutic targets",
author = "Abdel-Hamid, {Ibrahim A.} and Andersson, {Karl Erik} and Andrea Salonia",
year = "2011",
month = "3",
doi = "10.1517/14728222.2011.551008",
language = "English",
volume = "15",
pages = "325--340",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Exploration of therapeutic targets for sexual dysfunctions

T2 - Lessons learned from the failed stories

AU - Abdel-Hamid, Ibrahim A.

AU - Andersson, Karl Erik

AU - Salonia, Andrea

PY - 2011/3

Y1 - 2011/3

N2 - Introduction: The ratio between research and successful targets in a disease class gives a good indication about the extent of the exploration of additional targets for diseases in that class. This ratio is still very low for the field of sexual medicine. 'Failures' in drug development can be highly instructive, but are not often addressed. Areas covered: We performed a review of the literature based on published data on four failure stories including targeting adrenergic receptors for erectile dysfunction (ED), targeting dopamine receptors by apomorphine for ED, serotonergic transporters as a target for premature ejaculation and PDE5 as a target for female sexual dysfunctions. The search included: i) a MEDLINE search from 1966 through November 2010 limited to English language medical literature, ii) relevant abstracts from 2009 and 2010 and iii) a pipeline search for therapeutics in development. The aim is to inform readers about the lessons learned from four selected failed therapeutic stories during therapeutic target exploration for sexual dysfunctions. Expert opinion: By learning from failures, a drug may not only be kept alive, but also better therapeutic strategies and design of new drugs may be developed.

AB - Introduction: The ratio between research and successful targets in a disease class gives a good indication about the extent of the exploration of additional targets for diseases in that class. This ratio is still very low for the field of sexual medicine. 'Failures' in drug development can be highly instructive, but are not often addressed. Areas covered: We performed a review of the literature based on published data on four failure stories including targeting adrenergic receptors for erectile dysfunction (ED), targeting dopamine receptors by apomorphine for ED, serotonergic transporters as a target for premature ejaculation and PDE5 as a target for female sexual dysfunctions. The search included: i) a MEDLINE search from 1966 through November 2010 limited to English language medical literature, ii) relevant abstracts from 2009 and 2010 and iii) a pipeline search for therapeutics in development. The aim is to inform readers about the lessons learned from four selected failed therapeutic stories during therapeutic target exploration for sexual dysfunctions. Expert opinion: By learning from failures, a drug may not only be kept alive, but also better therapeutic strategies and design of new drugs may be developed.

KW - Adrenergic receptors

KW - Dopamine receptors

KW - Erectile dysfunction

KW - Female sexual dysfunctions

KW - Lessons learned

KW - PDE5 enzymes

KW - Premature ejaculation

KW - Serotonergic transporters

KW - Sexual dysfunctions

KW - Therapeutic targets

UR - http://www.scopus.com/inward/record.url?scp=79951651211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951651211&partnerID=8YFLogxK

U2 - 10.1517/14728222.2011.551008

DO - 10.1517/14728222.2011.551008

M3 - Article

C2 - 21204729

AN - SCOPUS:79951651211

VL - 15

SP - 325

EP - 340

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 3

ER -