Exploratory analysis of predictors of patient adherence to subcutaneous interferon beta-1a in multiple sclerosis: TRACER study

Damiano Paolicelli, Eleonora Cocco, Valentina Di Lecce, Vita Direnzo, Lucia Moiola, Roberta Lanzillo, Paola Perini, Simona Malucchi, Giovanna Borriello, Emilio Portaccio, Valentina Panetta, Giuseppe Fenu, Francesca Sangalli, Laura Cacciaguerra, Maria Trojano, the TRACER Group for the TRACER Group

Research output: Contribution to journalArticle

Abstract

Objective: The TRACER multicenter retrospective study aimed to collect data on treatment adherence in a real-life setting, in order to identify predictors of adherence at baseline. Methods: We recruited 384 relapsing-remitting (RR) multiple sclerosis patients with at least 12 months of use of RebiSmart®. This electronic device records the performed injections and assesses adherence as the percentage of ‘not missing doses’, through the connection to the iMed database. Subjects with at least 80% of completed doses at the 12 month of therapy were defined ‘treatment adherents’. Results: After 12 months, 89.3% of patients were adherent; 93.2% of patients aged 26–40 years at baseline were adherent (vs 79% of the ≤25 and 87.5% of the ≥41 year olds; p = 0.006). Furthermore, 90.5% of patients with a baseline Expanded Disability Status Scale (EDSS) score

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalExpert Opinion on Drug Delivery
DOIs
Publication statusAccepted/In press - Mar 13 2016

Keywords

  • Disease-modifying drugs
  • interferon beta
  • patient adherence
  • real-life setting
  • rebismart® injection device
  • relapsing-remitting multiple sclerosis

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Paolicelli, D., Cocco, E., Di Lecce, V., Direnzo, V., Moiola, L., Lanzillo, R., Perini, P., Malucchi, S., Borriello, G., Portaccio, E., Panetta, V., Fenu, G., Sangalli, F., Cacciaguerra, L., Trojano, M., & for the TRACER Group, T. TRACER. G. (Accepted/In press). Exploratory analysis of predictors of patient adherence to subcutaneous interferon beta-1a in multiple sclerosis: TRACER study. Expert Opinion on Drug Delivery, 1-7. https://doi.org/10.1517/17425247.2016.1158161