Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism

Maria Cristina Cavallini, Daniela Di Bella, Francesca Siliprandi, Francesca Malchiodi, Laura Bellodi

Research output: Contribution to journalArticlepeer-review

Abstract

The determination of a genetic basis for obsessive-compulsive disorder (OCD) depends on how phenotypic boundaries are defined. Although a hypothesis for serotonin dysfunction in OCD has been advanced, no genes specifically responsible for serotonin regulation have as yet been definitively related to the etiology of OCD. The phenotypic variability of OCD could be at the basis of the failure of molecular biology investigations to find any genes involved in the liability to the disorder. Obsessive and compulsive contents can aggregate in OCD patients differently; multifactorial description may therefore be able to account for OCD phenotypic variance. Using principal component analysis, we derived five factors from 13 main contents of the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and considered them as quantitative phenotypes to evaluate their possible association with an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR). A trend toward positive association between the fifth factor, including counting and repeating rituals, and 5-HTTLPR was found. However, only considering the subgroup of patients with tic codiagnosis, we found a significantly higher score for the fifth factor for patients with L/L genotype with respect to L/S and S/S genotypes.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume114
Issue number3
DOIs
Publication statusPublished - Apr 8 2002

Keywords

  • 5-HTTLPR
  • Factor scores
  • Principal component analysis
  • Serotonin
  • Tic disorders

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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