Exploring Bacteroidetes: Metabolic key points and immunological tricks of our gut commensals

Giulia Gibiino, Loris Riccardo Lopetuso, Franco Scaldaferri, Gianenrico Rizzatti, Cecilia Binda, Antonio Gasbarrini

Research output: Contribution to journalReview articlepeer-review


© 2018 Bacteroidetes are the largest phylum of Gram-negative bacteria inhabiting our gastrointestinal tract and are considered the leading players of the healthy state and sophisticated homeostasis safeguarded by gut microbiota. Furthermore, specific roles have been attributed to some Bacteroidetes genera in the development of immune dysregulation, systemic disease such as metabolic syndrome and also neurological disorders. Glycoproteins secretion, short fatty acids imbalance, toxins production and molecular mimicry are only a part of the functions exerted by these commensals interacting with the host. The aim of this review is to summarize the current knowledge on the recognized role of Bacteroidetes in physiological functions and pathological networks in order to define the needs for future research and clarify the potential role for targeted microbial therapies.
Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalDigestive and Liver Disease
Issue number7
Publication statusPublished - Jul 1 2018


  • Gut microbiota
  • Metabolic syndrome
  • Molecular mimicry
  • Neurologic disorders


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