Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia

Marco Spangaro; Marta Bosia; Andrea Zanoletti; Margherita Bechi; Buonocore Mariachiara; Adele Pirovano; Cristina Lorenzi; Placido Bramanti; Enrico Smeraldi; Roberto Cavallaro

doi:10.2217/pgs.14.42

Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia

Marco Spangaro, Marta Bosia, Andrea Zanoletti, Margherita Bechi, Buonocore Mariachiara, Adele Pirovano, Cristina Lorenzi, Placido Bramanti, Enrico Smeraldi, Roberto Cavallaro

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) of the excitatory amino acid transporters (EAAT1 and 2) on the cognitive dysfunction that characterizes schizophrenia. Materials & methods: One hundred and ninety two subjects diagnosed with schizophrenia were assessed with Brief Assessment of Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test and N-back test and genotyped for rs4354668 and rs2731880. Results: ANOVA showed a significant difference among both EAAT1 and EAAT2 genotype groups on different cognitive measures. Worse performances were observed among carriers of the genotypes associated with lower EAAT expression. Conclusion: Results suggest that impaired activity and EAAT expression could influence cognitive performances in schizophrenia, thus representing a target of interest for development of pharmacological strategies aimed to improve cognition.

Original language	English
Pages (from-to)	925-932
Number of pages	8
Journal	Pharmacogenomics
Volume	15
Issue number	7
DOIs	https://doi.org/10.2217/pgs.14.42
Publication status	Published - 2014

Keywords

cognitive impairment
EAAT1
EAAT2
glutamate uptake
schizophrenia

ASJC Scopus subject areas

Pharmacology
Genetics
Molecular Medicine
Medicine(all)

Access to Document

10.2217/pgs.14.42

Fingerprint Dive into the research topics of 'Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia'. Together they form a unique fingerprint.

Cite this

Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia. / Spangaro, Marco; Bosia, Marta; Zanoletti, Andrea; Bechi, Margherita; Mariachiara, Buonocore; Pirovano, Adele; Lorenzi, Cristina ; Bramanti, Placido; Smeraldi, Enrico; Cavallaro, Roberto.

In: Pharmacogenomics, Vol. 15, No. 7, 2014, p. 925-932.

Research output: Contribution to journal › Article › peer-review

@article{7bc219ac3a7c47679bf64566df75586d,

title = "Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia",

abstract = "Aim: To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) of the excitatory amino acid transporters (EAAT1 and 2) on the cognitive dysfunction that characterizes schizophrenia. Materials & methods: One hundred and ninety two subjects diagnosed with schizophrenia were assessed with Brief Assessment of Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test and N-back test and genotyped for rs4354668 and rs2731880. Results: ANOVA showed a significant difference among both EAAT1 and EAAT2 genotype groups on different cognitive measures. Worse performances were observed among carriers of the genotypes associated with lower EAAT expression. Conclusion: Results suggest that impaired activity and EAAT expression could influence cognitive performances in schizophrenia, thus representing a target of interest for development of pharmacological strategies aimed to improve cognition.",

keywords = "cognitive impairment, EAAT1, EAAT2, glutamate uptake, schizophrenia",

author = "Marco Spangaro and Marta Bosia and Andrea Zanoletti and Margherita Bechi and Buonocore Mariachiara and Adele Pirovano and Cristina Lorenzi and Placido Bramanti and Enrico Smeraldi and Roberto Cavallaro",

year = "2014",

doi = "10.2217/pgs.14.42",

language = "English",

volume = "15",

pages = "925--932",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Future Medicine Ltd.",

number = "7",

}

TY - JOUR

T1 - Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia

AU - Spangaro, Marco

AU - Bosia, Marta

AU - Zanoletti, Andrea

AU - Bechi, Margherita

AU - Mariachiara, Buonocore

AU - Pirovano, Adele

AU - Lorenzi, Cristina

AU - Bramanti, Placido

AU - Smeraldi, Enrico

AU - Cavallaro, Roberto

PY - 2014

Y1 - 2014

N2 - Aim: To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) of the excitatory amino acid transporters (EAAT1 and 2) on the cognitive dysfunction that characterizes schizophrenia. Materials & methods: One hundred and ninety two subjects diagnosed with schizophrenia were assessed with Brief Assessment of Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test and N-back test and genotyped for rs4354668 and rs2731880. Results: ANOVA showed a significant difference among both EAAT1 and EAAT2 genotype groups on different cognitive measures. Worse performances were observed among carriers of the genotypes associated with lower EAAT expression. Conclusion: Results suggest that impaired activity and EAAT expression could influence cognitive performances in schizophrenia, thus representing a target of interest for development of pharmacological strategies aimed to improve cognition.

AB - Aim: To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) of the excitatory amino acid transporters (EAAT1 and 2) on the cognitive dysfunction that characterizes schizophrenia. Materials & methods: One hundred and ninety two subjects diagnosed with schizophrenia were assessed with Brief Assessment of Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test and N-back test and genotyped for rs4354668 and rs2731880. Results: ANOVA showed a significant difference among both EAAT1 and EAAT2 genotype groups on different cognitive measures. Worse performances were observed among carriers of the genotypes associated with lower EAAT expression. Conclusion: Results suggest that impaired activity and EAAT expression could influence cognitive performances in schizophrenia, thus representing a target of interest for development of pharmacological strategies aimed to improve cognition.

KW - cognitive impairment

KW - EAAT1

KW - EAAT2

KW - glutamate uptake

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84903151904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903151904&partnerID=8YFLogxK

U2 - 10.2217/pgs.14.42

DO - 10.2217/pgs.14.42

M3 - Article

C2 - 24956246

AN - SCOPUS:84903151904

VL - 15

SP - 925

EP - 932

JO - Pharmacogenomics

JF - Pharmacogenomics

SN - 1462-2416

IS - 7

ER -

Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this