Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation

Norbert Latruffe, Allan Lançon, Raffaele Frazzi, Virginie Aires, Dominique Delmas, Jean Jacques Michaille, Fatima Djouadi, Jean Bastin, Mustapha Cherkaoui-Malki

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This review presents recent evidence implicating microRNAs (miRNAs) in the beneficial effects of resveratrol (trihydroxystilbene), a nonflavonoid plant polyphenol, with emphasis on its anti-inflammatory effects. Many diseases and pathologies have been linked, directly or indirectly, to inflammation. These include infections, injuries, atherosclerosis, diabetes mellitus, obesity, cancer, osteoarthritis, age-related macular degeneration, demyelination, and neurodegenerative diseases. Resveratrol can both decrease the secretion of proinflammatory cytokines (e.g., IL-6, IL-8, and TNF-α) and increase the production of anti-inflammatory cytokines; it also decreases the expression of adhesion proteins (e.g., ICAM-1) and leukocyte chemoattractants (e.g., MCP-1). Resveratrol's primary targets appear to be the transcription factors AP-1 and NF-κB, as well as the gene COX2. Although no mechanistic link between any particular miRNA and resveratrol has been identified, resveratrol effects depend at least in part upon the modification of the expression of a variety of miRNAs that can be anti-inflammatory (e.g., miR-663), proinflammatory (e.g., miR-155), tumor suppressing (e.g., miR-663), or oncogenic (e.g., miR-21).

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1348
Issue number1
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

MicroRNAs
Inflammation
Anti-Inflammatory Agents
Neurodegenerative diseases
Cytokines
Chemotactic Factors
Transcription Factor AP-1
Macular Degeneration
Polyphenols
Demyelinating Diseases
Pathology
Intercellular Adhesion Molecule-1
Medical problems
Interleukin-8
Osteoarthritis
Neurodegenerative Diseases
Tumors
Interleukin-6
Neoplasms
Atherosclerosis

Keywords

  • inflammation
  • miRNAs
  • regulation
  • resveratrol

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation. / Latruffe, Norbert; Lançon, Allan; Frazzi, Raffaele; Aires, Virginie; Delmas, Dominique; Michaille, Jean Jacques; Djouadi, Fatima; Bastin, Jean; Cherkaoui-Malki, Mustapha.

In: Annals of the New York Academy of Sciences, Vol. 1348, No. 1, 01.08.2015, p. 97-106.

Research output: Contribution to journalArticle

Latruffe, N, Lançon, A, Frazzi, R, Aires, V, Delmas, D, Michaille, JJ, Djouadi, F, Bastin, J & Cherkaoui-Malki, M 2015, 'Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation', Annals of the New York Academy of Sciences, vol. 1348, no. 1, pp. 97-106. https://doi.org/10.1111/nyas.12819
Latruffe, Norbert ; Lançon, Allan ; Frazzi, Raffaele ; Aires, Virginie ; Delmas, Dominique ; Michaille, Jean Jacques ; Djouadi, Fatima ; Bastin, Jean ; Cherkaoui-Malki, Mustapha. / Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation. In: Annals of the New York Academy of Sciences. 2015 ; Vol. 1348, No. 1. pp. 97-106.
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