Exploring the effect of previous inactivated influenza vaccination on seasonal influenza vaccine effectiveness against medically attended influenza: Results of the European I-MOVE multicentre test-negative case-control study, 2011/2012-2016/2017

I-MOVE primary care multicentre case-control team

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Abstract

Background: Results of previous influenza vaccination effects on current season influenza vaccine effectiveness (VE) are inconsistent. Objectives: To explore previous influenza vaccination effects on current season VE among population targeted for vaccination. Methods: We used 2011/2012 to 2016/2017 I-MOVE primary care multicentre test-negative data. For each season, we compared current season adjusted VE (aVE) between individuals vaccinated and unvaccinated in previous season. Using unvaccinated in both seasons as a reference, we then compared aVE between vaccinated in both seasons, current only, and previous only. Results: We included 941, 2645 and 959 influenza-like illness patients positive for influenza A(H1N1)pdm09, A(H3N2) and B, respectively, and 5532 controls. In 2011/2012, 2014/2015 and 2016/2017, A(H3N2) aVE point estimates among those vaccinated in previous season were −68%, −21% and −19%, respectively; among unvaccinated in previous season, these were 33%, 48% and 46%, respectively (aVE not computable for influenza A(H1N1)pdm09 and B). Compared to current season vaccination only, VE for both seasons' vaccination was (i) similar in two of four seasons for A(H3N2) (absolute difference [ad] 6% and 8%); (ii) lower in three of four seasons for influenza A(H1N1)pdm09 (ad 18%, 26% and 29%), in two seasons for influenza A(H3N2) (ad 27% and 39%) and in two of three seasons for influenza B (ad 26% and 37%); (iii) higher in one season for influenza A(H1N1)pdm09 (ad 20%) and influenza B (ad 24%). Conclusions: We did not identify any pattern of previous influenza vaccination effect. Prospective cohort studies documenting influenza infections, vaccinations and vaccine types are needed to understand previous influenza vaccinations' effects.

Original languageEnglish
Pages (from-to)567-581
Number of pages15
JournalInfluenza and other Respiratory Viruses
Volume12
Issue number5
DOIs
Publication statusPublished - Sep 1 2018

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Influenza Vaccines
Human Influenza
Case-Control Studies
Vaccination
Vaccines
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Keywords

  • case-control study
  • influenza
  • influenza vaccine
  • multicentre study
  • vaccine effectiveness

ASJC Scopus subject areas

  • Epidemiology
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

@article{e693eea5877d4975a674ae5cfbf343ae,
title = "Exploring the effect of previous inactivated influenza vaccination on seasonal influenza vaccine effectiveness against medically attended influenza: Results of the European I-MOVE multicentre test-negative case-control study, 2011/2012-2016/2017",
abstract = "Background: Results of previous influenza vaccination effects on current season influenza vaccine effectiveness (VE) are inconsistent. Objectives: To explore previous influenza vaccination effects on current season VE among population targeted for vaccination. Methods: We used 2011/2012 to 2016/2017 I-MOVE primary care multicentre test-negative data. For each season, we compared current season adjusted VE (aVE) between individuals vaccinated and unvaccinated in previous season. Using unvaccinated in both seasons as a reference, we then compared aVE between vaccinated in both seasons, current only, and previous only. Results: We included 941, 2645 and 959 influenza-like illness patients positive for influenza A(H1N1)pdm09, A(H3N2) and B, respectively, and 5532 controls. In 2011/2012, 2014/2015 and 2016/2017, A(H3N2) aVE point estimates among those vaccinated in previous season were −68{\%}, −21{\%} and −19{\%}, respectively; among unvaccinated in previous season, these were 33{\%}, 48{\%} and 46{\%}, respectively (aVE not computable for influenza A(H1N1)pdm09 and B). Compared to current season vaccination only, VE for both seasons' vaccination was (i) similar in two of four seasons for A(H3N2) (absolute difference [ad] 6{\%} and 8{\%}); (ii) lower in three of four seasons for influenza A(H1N1)pdm09 (ad 18{\%}, 26{\%} and 29{\%}), in two seasons for influenza A(H3N2) (ad 27{\%} and 39{\%}) and in two of three seasons for influenza B (ad 26{\%} and 37{\%}); (iii) higher in one season for influenza A(H1N1)pdm09 (ad 20{\%}) and influenza B (ad 24{\%}). Conclusions: We did not identify any pattern of previous influenza vaccination effect. Prospective cohort studies documenting influenza infections, vaccinations and vaccine types are needed to understand previous influenza vaccinations' effects.",
keywords = "case-control study, influenza, influenza vaccine, multicentre study, vaccine effectiveness",
author = "{I-MOVE primary care multicentre case-control team} and Marta Valenciano and Esther Kissling and Amparo Larrauri and Baltazar Nunes and Daniela Pitigoi and Joan O'Donnell and Annicka Reuss and Horv{\'a}th, {Judit Krisztina} and Iwona Paradowska-Stankiewicz and Caterina Rizzo and Alessandra Falchi and Isabelle Daviaud and Mia Brytting and Adam Meijer and Bernard Kaic and Alin Gherasim and Ausenda Machado and Alina Ivanciuc and Lisa Domegan and Brunhilde Schweiger and Annam{\'a}ria Ferenczi and Monika Korczyńska and Antonino Bella and Vilcu, {Ana Maria} and Anne Mosnier and Katherina Zakikhany and {de Lange}, Marit and {Kurečić Filipovićović}, Sanja and Kari Johansen and Alain Moren",
year = "2018",
month = "9",
day = "1",
doi = "10.1111/irv.12562",
language = "English",
volume = "12",
pages = "567--581",
journal = "Influenza and other Respiratory Viruses",
issn = "1750-2640",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Exploring the effect of previous inactivated influenza vaccination on seasonal influenza vaccine effectiveness against medically attended influenza

T2 - Results of the European I-MOVE multicentre test-negative case-control study, 2011/2012-2016/2017

AU - I-MOVE primary care multicentre case-control team

AU - Valenciano, Marta

AU - Kissling, Esther

AU - Larrauri, Amparo

AU - Nunes, Baltazar

AU - Pitigoi, Daniela

AU - O'Donnell, Joan

AU - Reuss, Annicka

AU - Horváth, Judit Krisztina

AU - Paradowska-Stankiewicz, Iwona

AU - Rizzo, Caterina

AU - Falchi, Alessandra

AU - Daviaud, Isabelle

AU - Brytting, Mia

AU - Meijer, Adam

AU - Kaic, Bernard

AU - Gherasim, Alin

AU - Machado, Ausenda

AU - Ivanciuc, Alina

AU - Domegan, Lisa

AU - Schweiger, Brunhilde

AU - Ferenczi, Annamária

AU - Korczyńska, Monika

AU - Bella, Antonino

AU - Vilcu, Ana Maria

AU - Mosnier, Anne

AU - Zakikhany, Katherina

AU - de Lange, Marit

AU - Kurečić Filipovićović, Sanja

AU - Johansen, Kari

AU - Moren, Alain

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Results of previous influenza vaccination effects on current season influenza vaccine effectiveness (VE) are inconsistent. Objectives: To explore previous influenza vaccination effects on current season VE among population targeted for vaccination. Methods: We used 2011/2012 to 2016/2017 I-MOVE primary care multicentre test-negative data. For each season, we compared current season adjusted VE (aVE) between individuals vaccinated and unvaccinated in previous season. Using unvaccinated in both seasons as a reference, we then compared aVE between vaccinated in both seasons, current only, and previous only. Results: We included 941, 2645 and 959 influenza-like illness patients positive for influenza A(H1N1)pdm09, A(H3N2) and B, respectively, and 5532 controls. In 2011/2012, 2014/2015 and 2016/2017, A(H3N2) aVE point estimates among those vaccinated in previous season were −68%, −21% and −19%, respectively; among unvaccinated in previous season, these were 33%, 48% and 46%, respectively (aVE not computable for influenza A(H1N1)pdm09 and B). Compared to current season vaccination only, VE for both seasons' vaccination was (i) similar in two of four seasons for A(H3N2) (absolute difference [ad] 6% and 8%); (ii) lower in three of four seasons for influenza A(H1N1)pdm09 (ad 18%, 26% and 29%), in two seasons for influenza A(H3N2) (ad 27% and 39%) and in two of three seasons for influenza B (ad 26% and 37%); (iii) higher in one season for influenza A(H1N1)pdm09 (ad 20%) and influenza B (ad 24%). Conclusions: We did not identify any pattern of previous influenza vaccination effect. Prospective cohort studies documenting influenza infections, vaccinations and vaccine types are needed to understand previous influenza vaccinations' effects.

AB - Background: Results of previous influenza vaccination effects on current season influenza vaccine effectiveness (VE) are inconsistent. Objectives: To explore previous influenza vaccination effects on current season VE among population targeted for vaccination. Methods: We used 2011/2012 to 2016/2017 I-MOVE primary care multicentre test-negative data. For each season, we compared current season adjusted VE (aVE) between individuals vaccinated and unvaccinated in previous season. Using unvaccinated in both seasons as a reference, we then compared aVE between vaccinated in both seasons, current only, and previous only. Results: We included 941, 2645 and 959 influenza-like illness patients positive for influenza A(H1N1)pdm09, A(H3N2) and B, respectively, and 5532 controls. In 2011/2012, 2014/2015 and 2016/2017, A(H3N2) aVE point estimates among those vaccinated in previous season were −68%, −21% and −19%, respectively; among unvaccinated in previous season, these were 33%, 48% and 46%, respectively (aVE not computable for influenza A(H1N1)pdm09 and B). Compared to current season vaccination only, VE for both seasons' vaccination was (i) similar in two of four seasons for A(H3N2) (absolute difference [ad] 6% and 8%); (ii) lower in three of four seasons for influenza A(H1N1)pdm09 (ad 18%, 26% and 29%), in two seasons for influenza A(H3N2) (ad 27% and 39%) and in two of three seasons for influenza B (ad 26% and 37%); (iii) higher in one season for influenza A(H1N1)pdm09 (ad 20%) and influenza B (ad 24%). Conclusions: We did not identify any pattern of previous influenza vaccination effect. Prospective cohort studies documenting influenza infections, vaccinations and vaccine types are needed to understand previous influenza vaccinations' effects.

KW - case-control study

KW - influenza

KW - influenza vaccine

KW - multicentre study

KW - vaccine effectiveness

UR - http://www.scopus.com/inward/record.url?scp=85046677672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046677672&partnerID=8YFLogxK

U2 - 10.1111/irv.12562

DO - 10.1111/irv.12562

M3 - Article

AN - SCOPUS:85046677672

VL - 12

SP - 567

EP - 581

JO - Influenza and other Respiratory Viruses

JF - Influenza and other Respiratory Viruses

SN - 1750-2640

IS - 5

ER -