Exploring the Functionalization of Polymeric Nanoparticles Based on Cyclodextrins for Tumor Cell Targeting

Carmela Giachino, Maurizio Viale, Graziella Vecchio

Research output: Contribution to journalArticle

Abstract

Abstract Some nanotherapeutics based on cyclodextrin polymers are currently undergoing clinical trials. In light of this interest, we synthesized new linear polymers based on ?-cyclodextrins containing targeting units, such as biotin or arginine, to explore the advantage of functionalization for drug delivery. The polymers increased doxorubicin solubility. Furthermore, they slightly enhanced doxorubicin cytotoxicity in A2780 cells. In particular, the polymer containing arginine moieties was the most effective system by increasing doxorubicin cytotoxicity by 50%.
Original languageEnglish
Pages (from-to)13025-13028
Number of pages4
JournalChemistrySelect
Volume4
Issue number44
DOIs
Publication statusPublished - 2019

Keywords

  • arginine
  • biotin
  • cancer
  • doxorubicin
  • tumor

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