Exploring the genetic diversity of the 16S rRNA gene of Akkermansia muciniphila in IBD and IBS

Alessandra Lo Presti, Federica Del Chierico, Annamaria Altomare, Francesca Zorzi, Eleonora Cella, Lorenza Putignani, Michele Pier Luca Guarino, Giovanni Monteleone, Michele Cicala, Silvia Angeletti, Massimo Ciccozzi

Research output: Contribution to journalArticlepeer-review


Aim: The human gastrointestinal tract harbors diverse, abundant microbiota and Akkermansia muciniphila is involved in this community. The aim of this study is to characterize 16 new A. muciniphila 16S ribosomal RNA sequences selected from a metagenomic database from stools of patients with irritable bowel syndrome (IBS), inflammatory bowel diseases and control (CTRLs) subjects by a phylogenetic approach. Materials methods: A phylogenetic approach was used to study the genetic diversity and SNPs in 16 A. muciniphila 16S ribosomal RNA sequences from stools of 107 individuals, 36 of which were patients affected by IBS, 30 by inflammatory bowel disease and 41 were CTRLs. Results: Phylogenetic analysis confirmed the subdivision into different supported clusters. An increase of variability in IBS has been identified. Conclusion: The genetic variation combined to the relative abundance, contribute to the protective role of A. muciniphila. Phylogenesis represent an additional approach to investigate genetic variability.
Original languageEnglish
Pages (from-to)1497-1509
Number of pages13
JournalFuture Microbiology
Issue number17
Publication statusPublished - Nov 1 2019


  • Akkermansia muciniphila
  • inflammatory bowel disease
  • irritable bowel syndrome
  • microbiota
  • phylogenesis


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