Exploring the microbiota to better understand gastrointestinal cancers physiology

Research output: Contribution to journalReview article

Abstract

Gastrointestinal cancers account for around 40% of cancer-related deaths worldwide, representing a global health burden. There is a growing body of evidence highlighting the link between microbiota and gastrointestinal tumorigenesis and/or resistance to therapy. In the present manuscript, we reviewed the published studies on the relationship between the microbiota and the different gastrointestinal tumors, namely, gastric, colorectal and esophageal, including also the cancer of accessory organs such as liver and pancreas. There is an emergent interest in the manipulation of gastrointestinal microflora in order to understand the gastrointestinal tumorigenesis' processes and the establishment of chemoresistance mechanisms.

Original languageEnglish
Pages (from-to)1400-1412
Number of pages13
JournalClinical Chemistry and Laboratory Medicine
Volume56
Issue number9
DOIs
Publication statusPublished - Aug 28 2018

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Keywords

  • accessory organs
  • chemoresistance
  • gastrointestinal cancers
  • metagenomics
  • microbiota

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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