Exploring the molecular aspects associated with testicular germ cell tumors: A review

Gaetano Facchini, Sabrina Rossetti, Carla Cavaliere, Carmine D'Aniello, Rossella Di Franco, Gelsomina Iovane, Giovanni Grimaldi, Raffaele Piscitelli, Paolo Muto, Gerardo Botti, Sisto Perdonà, Bianca Maria Veneziani, Massimiliano Berretta, Micaela Montanari

Research output: Contribution to journalReview articlepeer-review

Abstract

Testicular germ cell tumors (TGCTs) represent the most common solid tumors affecting young men. They constitute a distinct entity because of their embryonic origin and their unique biological behavior. Recent preclinical data regarding biological signaling machinery as well as genetic and epigenetic mechanisms associated with molecular patterns of tumors have contribute to explain the pathogenesis and the differentiation of TGCTs and to understand the mechanisms responsible for the development of resistance to treatment. In this review, we discuss the main genetic and epigenetic events associated with TGCTs development in order to better define their role in the pathogenesis of these tumors and in cisplatin-acquired resistance.

Original languageEnglish
Pages (from-to)1365-1379
Number of pages15
JournalOncotarget
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Chemosensitivity
  • Cisplatin-associated resistance
  • Epigenetics
  • TGCTs

ASJC Scopus subject areas

  • Oncology

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