Exploring the Molecular Pathways behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications

Gregorio Peron, Nicole Hidalgo-Liberona, Raúl González-Domínguez, Mar Garcia-Aloy, Simone Guglielmetti, Stefano Bernardi, Benjamin Kirkup, Paul Antony Kroon, Antonio Cherubini, Patrizia Riso, Cristina Andrés-Lacueva

Research output: Contribution to journalReview articlepeer-review

Abstract

The gut microbiota is involved in the regulation of the intestinal permeability (IP), whose disruption is a frequent condition in older people and is associated with the development of several diseases. The diet can affect the gut microbiota and IP, although the molecular mechanisms involved are unclear. Metabolomics is one of the suitable approaches to study the effects of diet on gut microbiota and IP, although, up to now, the research has focused only on a few dietary components. The aim here was to review the most recent literature concerning the application of metabolomics to the study of the diet-induced alterations of gut microbiota and the effects on IP, with a particular focus on the molecular pathways involved. An additional aim was to give a perspective on the future research involving dietary polyphenols, because despite their potential use in the management of increased IP, few studies have been reported to date.

Original languageEnglish
JournalJournal of Agricultural and Food Chemistry
DOIs
Publication statusPublished - May 14 2019

Keywords

  • aging
  • gut microbiota
  • intestinal permeability
  • metabolomics
  • nutrients
  • polyphenols

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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