Exploring the morphological and functional retinal changes after dexamethasone intravitreal implant (Ozurdex®) in Macular Edema due to retinal vein occlusion

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Abstract

Purpose: To explore functional and morphological retinal changes 6 months after dexamethasone intravitreal implant (DEX implant) for the treatment of macular edema due to central or branch retinal vein occlusion (CRVO, BRVO). Procedures: In this prospective interventional case series patients underwent a complete ophthalmological examination at baseline and monthly, including best-corrected visual acuity (BCVA), spectral domain-optical coherence tomography and microperimetry. Fluorescein angiography was performed at baseline and at 4 months. All patients were treated with a DEX implant and retreated according to predefined criteria starting from month 4. Results: Sixteen patients (mean age 66 ± 13 years, 14 CRVO, 2 BRVO) were included. At 6 months mean retinal sensitivity improved from 9.7 ± 4.6 to 13.6 ± 5.4 dB (p <0.0001) while mean BCVA improved from 52.4 ± 16.2 to 66.1 ± 16.6 (p <0.0001). Mean central retinal thickness decreased from 708.3 ± 151.01 to 362.7 ± 177.4 μm (p <0.0001); 56.2% of eyes were retreated at month 4. Conclusions: At 6 months DEX implant led to a significant improvement in retinal sensitivity and visual acuity associated with a reduction of retinal thickness in patients with macular edema due to retinal vein occlusion.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalOphthalmic Research
Volume51
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Dexamethasone
  • Intravitreal implant
  • Macular edema
  • Microperimetry
  • Retinal vein occlusion

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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