Exploring the potential of generative adversarial networks for synthesizing radiological images of the spine to be used in in silico trials

Fabio Galbusera, Frank Niemeyer, Maike Seyfried, Tito Bassani, Gloria Casaroli, Annette Kienle, Hans Joachim Wilke

Research output: Contribution to journalArticle

Abstract

In silico trials recently emerged as a disruptive technology, which may reduce the costs related to the development and marketing approval of novel medical technologies, as well as shortening their time-to-market. In these trials, virtual patients are recruited from a large database and their response to the therapy, such as the implantation of a medical device, is simulated by means of numerical models. In this work, we propose the use of generative adversarial networks to produce synthetic radiological images to be used in in silico trials. The generative models produced credible synthetic sagittal X-rays of the lumbar spine based on a simple sketch, and were able to generate sagittal radiological images of the trunk using coronal projections as inputs, and vice versa. Although numerous inaccuracies in the anatomical details may still allow distinguishing synthetic and real images in the majority of cases, the present work showed that generative models are a feasible solution for creating synthetic imaging data to be used in in silico trials of novel medical devices.

Original languageEnglish
Article number53
JournalFrontiers in Bioengineering and Biotechnology
Volume6
Issue numberMAY
DOIs
Publication statusPublished - May 3 2018

Keywords

  • Generative adversarial networks
  • Generative models
  • In silico trial
  • Spine imaging
  • Synthetic image
  • Synthetic spine radiology

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering

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