Exploring the Prognostic Role of Microsatellite Instability in Patients With Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis

Adriana Romiti, Eliana Rulli, Emanuela Pilozzi, Chiara Gerardi, Michela Roberto, Lorenzo Legramandi, Rosa Falcone, Ilaria Pacchetti, Paolo Marchetti, Irene Floriani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Many studies have disclosed the prognostic effect of microsatellite instability (MSI) and/or loss of mismatch repair proteins in colorectal cancer. Nevertheless, little evidence supports their role in the decision-making of adjuvant therapy for patients with stage II disease. Materials and Methods: The aim of this systematic review was to evaluate the prognostic and/or predictive role of MSI status in patients with stage II colorectal cancer on disease-free survival and overall survival. MEDLINE, EMBASE, and Cochrane libraries were searched to identify eligible studies. Results: Only 2 of 389 articles identified fulfilled the eligibility criteria. In both treated and untreated patients, high-level MSI improved disease-free survival compared with low-level MSI, suggesting a prognostic role but not supporting the hypothesis of a predictive effect of MSI. Conclusions: Further studies are needed to explore the predictive role of MSI/mismatch repair proteins, because available data do not allow definitive conclusions.

Original languageEnglish
JournalClinical Colorectal Cancer
DOIs
Publication statusAccepted/In press - Feb 25 2016

Fingerprint

Microsatellite Instability
Meta-Analysis
Colorectal Neoplasms
DNA Mismatch Repair
Disease-Free Survival
MEDLINE
Libraries
Decision Making
Proteins
Survival

Keywords

  • Adjuvant therapy
  • Colorectal cancer
  • Mismatch repair proteins
  • Predictive factor
  • Prognostic factor

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Exploring the Prognostic Role of Microsatellite Instability in Patients With Stage II Colorectal Cancer : A Systematic Review and Meta-Analysis. / Romiti, Adriana; Rulli, Eliana; Pilozzi, Emanuela; Gerardi, Chiara; Roberto, Michela; Legramandi, Lorenzo; Falcone, Rosa; Pacchetti, Ilaria; Marchetti, Paolo; Floriani, Irene.

In: Clinical Colorectal Cancer, 25.02.2016.

Research output: Contribution to journalArticle

Romiti, Adriana ; Rulli, Eliana ; Pilozzi, Emanuela ; Gerardi, Chiara ; Roberto, Michela ; Legramandi, Lorenzo ; Falcone, Rosa ; Pacchetti, Ilaria ; Marchetti, Paolo ; Floriani, Irene. / Exploring the Prognostic Role of Microsatellite Instability in Patients With Stage II Colorectal Cancer : A Systematic Review and Meta-Analysis. In: Clinical Colorectal Cancer. 2016.
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AU - Gerardi, Chiara

AU - Roberto, Michela

AU - Legramandi, Lorenzo

AU - Falcone, Rosa

AU - Pacchetti, Ilaria

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