Exploring the relationships between inflammatory response and coagulation cascade in inflammatory bowel disease

S. Saibeni, L. Spina, M. Vecchi

Research output: Contribution to journalArticle

Abstract

Background: The inflammatory network and the coagulation cascade are strictly correlated biological systems. Inflammatory Bowel Diseases (IBD) are characterised by a prothrombotic state, a hypercoagulability state and an increased prevalence of thromboembolic events. Methods: We reviewed the IBD literature in which the relationships between inflammation and coagulation were evaluated. Results: Several risk factors and mechanisms have been suggested to be implicated in determining the increased risk for thrombosis of IBD. Even if IBD may be per se a prothrombotic condition, systemic inflammation and vitamin deficiencies appear to play a relevant role in determining such a risk. Conclusions: A good and continuous control of the intestinal disease and vitamin supplementation are strongly recommended in order to correct some of the risk factors for thrombosis in IBD patients.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalEuropean Review for Medical and Pharmacological Sciences
Volume8
Issue number5
Publication statusPublished - Sep 2004

Keywords

  • Coagulation
  • Inflammation
  • Inflammatory bowel disease
  • Thrombosis

ASJC Scopus subject areas

  • Pharmacology

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