Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer

Michela Coan, Gian Luca Rampioni Vinciguerra, Laura Cesaratto, Emanuela Gardenal, Riccardo Bianchet, Erik Dassi, Andrea Vecchione, Gustavo Baldassarre, Riccardo Spizzo, Milena Sabrina Nicoloso

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Tumor characteristics (e.g., risk factors and epidemiology) are valuable clues to accomplish this task. The two most frequent risk factors for HGSOC are the lifetime number of ovulations, which is associated with increased oxidative stress in the pelvic area caused by ovulation fluid, and a positive family history due to genetic factors. In the attempt to identify novel genetic factors (i.e., genes) associated with HGSOC, we observed that several genes in linkage with HGSOC are expressed in the ciliated cells of the fallopian tube. This finding made us hypothesize that ciliated cells, despite not being the cell of origin for HGSOC, may take part in HGSOC tumor initiation. Specifically, malfunction of the ciliary beat impairs the laminar fluid flow above the fallopian tube epithelia, thus likely reducing the clearance of oxidative stress caused by follicular fluid. Herein, we review the up-to-date findings dealing with HGSOC predisposition with the hypothesis that fallopian ciliated cells take part in HGSOC onset. Finally, we review the up-to-date literature concerning genes that are located in genomic loci associated with epithelial ovarian cancer (EOC) predisposition that are expressed by the fallopian ciliated cells.

Original languageEnglish
Article number2512
JournalInternational Journal of Molecular Sciences
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

Fingerprint

pathogenesis
Ovarian Neoplasms
Tumors
grade
Oxidative stress
Genes
cancer
cells
Epidemiology
Chemotherapy
Fluids
Flow of fluids
genes
Fallopian Tubes
tumors
Neoplasms
Ovulation
Oxidative Stress
Ovarian epithelial cancer
epidemiology

Keywords

  • C20orf85
  • CCDC170
  • Ciliated cells
  • DNAAF1
  • Epithelial ovarian cancer
  • LRP2BP
  • LRRC46
  • MARCH10
  • Predisposition
  • RSPH10B2
  • SPAG6
  • STK33
  • TPPP

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer. / Coan, Michela; Vinciguerra, Gian Luca Rampioni; Cesaratto, Laura; Gardenal, Emanuela; Bianchet, Riccardo; Dassi, Erik; Vecchione, Andrea; Baldassarre, Gustavo; Spizzo, Riccardo; Nicoloso, Milena Sabrina.

In: International Journal of Molecular Sciences, Vol. 19, No. 9, 2512, 01.09.2018.

Research output: Contribution to journalReview article

Coan, Michela ; Vinciguerra, Gian Luca Rampioni ; Cesaratto, Laura ; Gardenal, Emanuela ; Bianchet, Riccardo ; Dassi, Erik ; Vecchione, Andrea ; Baldassarre, Gustavo ; Spizzo, Riccardo ; Nicoloso, Milena Sabrina. / Exploring the role of fallopian ciliated cells in the pathogenesis of high-grade serous ovarian cancer. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 9.
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abstract = "High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Tumor characteristics (e.g., risk factors and epidemiology) are valuable clues to accomplish this task. The two most frequent risk factors for HGSOC are the lifetime number of ovulations, which is associated with increased oxidative stress in the pelvic area caused by ovulation fluid, and a positive family history due to genetic factors. In the attempt to identify novel genetic factors (i.e., genes) associated with HGSOC, we observed that several genes in linkage with HGSOC are expressed in the ciliated cells of the fallopian tube. This finding made us hypothesize that ciliated cells, despite not being the cell of origin for HGSOC, may take part in HGSOC tumor initiation. Specifically, malfunction of the ciliary beat impairs the laminar fluid flow above the fallopian tube epithelia, thus likely reducing the clearance of oxidative stress caused by follicular fluid. Herein, we review the up-to-date findings dealing with HGSOC predisposition with the hypothesis that fallopian ciliated cells take part in HGSOC onset. Finally, we review the up-to-date literature concerning genes that are located in genomic loci associated with epithelial ovarian cancer (EOC) predisposition that are expressed by the fallopian ciliated cells.",
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AU - Bianchet, Riccardo

AU - Dassi, Erik

AU - Vecchione, Andrea

AU - Baldassarre, Gustavo

AU - Spizzo, Riccardo

AU - Nicoloso, Milena Sabrina

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