Exploring unknowns in cardiology

Ottavio Alfieri, Bongani M. Mayosi, Seung Jung Park, Nizal Sarrafzadegan, Renu Virmani

Research output: Contribution to journalArticlepeer-review


To mark the 10 th anniversary of Nature Reviews Cardiology in November 2014, five of our Advisory Board members were invited to consider a topic within cardiology about which we know too little. A diverse range of subjects are highlighted in this Perspectives article, including preoperative assessment of right ventricular function, the burden of cardiomyopathies in Africa, the measurement of fractional flow reserve to guide coronary intervention, the interaction between genes and environment in cardiovascular disease, and the difficulty of predicting atherosclerotic plaque rupture. The five key opinion leaders from around the globe also suggest ways in which future research could be targeted to address the deficits in our understanding, with the aim of preventing cardiovascular disease, improving patient care, and reducing morbidity and mortality.

Original languageEnglish
Pages (from-to)664-670
Number of pages7
JournalNature Reviews Cardiology
Issue number11
Publication statusPublished - Nov 25 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


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