Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada

Ann C. Olsson, Per Gustavsson, Hans Kromhout, Susan Peters, Roel Vermeulen, Irene Brüske, Beate Pesch, Jack Siemiatycki, Javier Pintos, Thomas Brüning, Adrian Cassidy, Heinz Erich Wichmann, Dario Consonni, Maria Teresa Landi, Neil Caporaso, Nils Plato, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Karl Heinz JöckelWolfgang Ahrens, Hermann Pohlabeln, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, David Zaridze, Isabelle Stücker, Simone Benhamou, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Isabelle M. Gross, Benjamin Kendzia, Francesco Forastiere, Bas Bueno-de-Mesquita, Paul Brennan, Paolo Boffetta, Kurt Straif

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95%confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value <0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and neversmokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models ands ubgroup analyses.

Original languageEnglish
Pages (from-to)941-948
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume183
Issue number7
DOIs
Publication statusPublished - Apr 1 2011

Fingerprint

Vehicle Emissions
Canada
Case-Control Studies
Lung Neoplasms
Occupational Exposure
Occupations
Smoking
Odds Ratio
Confidence Intervals
International Agencies
Tobacco Products
Logistic Models
Research
Population
Neoplasms

Keywords

  • Epidemiologic studies
  • Lung neoplasm
  • Occupational exposure
  • Vehicle emissions

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. / Olsson, Ann C.; Gustavsson, Per; Kromhout, Hans; Peters, Susan; Vermeulen, Roel; Brüske, Irene; Pesch, Beate; Siemiatycki, Jack; Pintos, Javier; Brüning, Thomas; Cassidy, Adrian; Wichmann, Heinz Erich; Consonni, Dario; Landi, Maria Teresa; Caporaso, Neil; Plato, Nils; Merletti, Franco; Mirabelli, Dario; Richiardi, Lorenzo; Jöckel, Karl Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Zaridze, David; Stücker, Isabelle; Benhamou, Simone; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Rudnai, Peter; Fabianova, Eleonora; Dumitru, Rodica Stanescu; Gross, Isabelle M.; Kendzia, Benjamin; Forastiere, Francesco; Bueno-de-Mesquita, Bas; Brennan, Paul; Boffetta, Paolo; Straif, Kurt.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 183, No. 7, 01.04.2011, p. 941-948.

Research output: Contribution to journalArticle

Olsson, AC, Gustavsson, P, Kromhout, H, Peters, S, Vermeulen, R, Brüske, I, Pesch, B, Siemiatycki, J, Pintos, J, Brüning, T, Cassidy, A, Wichmann, HE, Consonni, D, Landi, MT, Caporaso, N, Plato, N, Merletti, F, Mirabelli, D, Richiardi, L, Jöckel, KH, Ahrens, W, Pohlabeln, H, Lissowska, J, Szeszenia-Dabrowska, N, Zaridze, D, Stücker, I, Benhamou, S, Bencko, V, Foretova, L, Janout, V, Rudnai, P, Fabianova, E, Dumitru, RS, Gross, IM, Kendzia, B, Forastiere, F, Bueno-de-Mesquita, B, Brennan, P, Boffetta, P & Straif, K 2011, 'Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada', American Journal of Respiratory and Critical Care Medicine, vol. 183, no. 7, pp. 941-948. https://doi.org/10.1164/rccm.201006-0940OC
Olsson, Ann C. ; Gustavsson, Per ; Kromhout, Hans ; Peters, Susan ; Vermeulen, Roel ; Brüske, Irene ; Pesch, Beate ; Siemiatycki, Jack ; Pintos, Javier ; Brüning, Thomas ; Cassidy, Adrian ; Wichmann, Heinz Erich ; Consonni, Dario ; Landi, Maria Teresa ; Caporaso, Neil ; Plato, Nils ; Merletti, Franco ; Mirabelli, Dario ; Richiardi, Lorenzo ; Jöckel, Karl Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Zaridze, David ; Stücker, Isabelle ; Benhamou, Simone ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Rudnai, Peter ; Fabianova, Eleonora ; Dumitru, Rodica Stanescu ; Gross, Isabelle M. ; Kendzia, Benjamin ; Forastiere, Francesco ; Bueno-de-Mesquita, Bas ; Brennan, Paul ; Boffetta, Paolo ; Straif, Kurt. / Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. In: American Journal of Respiratory and Critical Care Medicine. 2011 ; Vol. 183, No. 7. pp. 941-948.
@article{2a545d9a591f429289fc898ad4569843,
title = "Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada",
abstract = "Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95{\%} confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95{\%}confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value <0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and neversmokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models ands ubgroup analyses.",
keywords = "Epidemiologic studies, Lung neoplasm, Occupational exposure, Vehicle emissions",
author = "Olsson, {Ann C.} and Per Gustavsson and Hans Kromhout and Susan Peters and Roel Vermeulen and Irene Br{\"u}ske and Beate Pesch and Jack Siemiatycki and Javier Pintos and Thomas Br{\"u}ning and Adrian Cassidy and Wichmann, {Heinz Erich} and Dario Consonni and Landi, {Maria Teresa} and Neil Caporaso and Nils Plato and Franco Merletti and Dario Mirabelli and Lorenzo Richiardi and J{\"o}ckel, {Karl Heinz} and Wolfgang Ahrens and Hermann Pohlabeln and Jolanta Lissowska and Neonila Szeszenia-Dabrowska and David Zaridze and Isabelle St{\"u}cker and Simone Benhamou and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Peter Rudnai and Eleonora Fabianova and Dumitru, {Rodica Stanescu} and Gross, {Isabelle M.} and Benjamin Kendzia and Francesco Forastiere and Bas Bueno-de-Mesquita and Paul Brennan and Paolo Boffetta and Kurt Straif",
year = "2011",
month = "4",
day = "1",
doi = "10.1164/rccm.201006-0940OC",
language = "English",
volume = "183",
pages = "941--948",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society - AJRCCM",
number = "7",

}

TY - JOUR

T1 - Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada

AU - Olsson, Ann C.

AU - Gustavsson, Per

AU - Kromhout, Hans

AU - Peters, Susan

AU - Vermeulen, Roel

AU - Brüske, Irene

AU - Pesch, Beate

AU - Siemiatycki, Jack

AU - Pintos, Javier

AU - Brüning, Thomas

AU - Cassidy, Adrian

AU - Wichmann, Heinz Erich

AU - Consonni, Dario

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Plato, Nils

AU - Merletti, Franco

AU - Mirabelli, Dario

AU - Richiardi, Lorenzo

AU - Jöckel, Karl Heinz

AU - Ahrens, Wolfgang

AU - Pohlabeln, Hermann

AU - Lissowska, Jolanta

AU - Szeszenia-Dabrowska, Neonila

AU - Zaridze, David

AU - Stücker, Isabelle

AU - Benhamou, Simone

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Dumitru, Rodica Stanescu

AU - Gross, Isabelle M.

AU - Kendzia, Benjamin

AU - Forastiere, Francesco

AU - Bueno-de-Mesquita, Bas

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Straif, Kurt

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95%confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value <0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and neversmokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models ands ubgroup analyses.

AB - Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95%confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value <0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and neversmokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models ands ubgroup analyses.

KW - Epidemiologic studies

KW - Lung neoplasm

KW - Occupational exposure

KW - Vehicle emissions

UR - http://www.scopus.com/inward/record.url?scp=79953309084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953309084&partnerID=8YFLogxK

U2 - 10.1164/rccm.201006-0940OC

DO - 10.1164/rccm.201006-0940OC

M3 - Article

C2 - 21037020

AN - SCOPUS:79953309084

VL - 183

SP - 941

EP - 948

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 7

ER -