Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers

John Vena, Paolo Boffetta, Heiko Becher, Trevor Benn, H. Bas Bueno-de-Mesquita, David Coggon, Didier Colin, Dieter Flesch-Janys, Lois Green, Timo Kauppinen, Margareta Littorin, Elsebeth Lynge, John D. Mathews, Manfred Neuberger, Neil Pearce, Angela C. Pesatori, Rodolfo Saracci, Kyle Steenland, Manolis Kogevinas

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed from 1939 to 1992. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin or higher chlorinated dioxins (TCDD/HCD) was discerned from job records and company questionnaires with validation by biologic and environmental measures. Standard mortality ratio analyses suggested a moderate healthy worker effect for all circulatory diseases, especially ischemic heart disease, among both those exposed and those not exposed to TCDD/HCD. In Poisson regression analyses, exposure to TCDD/HCD was not associated with increased mortality from cerebrovascular disease. However, an increased risk for circulatory disease, especially ischemic heart disease (rate ratio [RR] 1.67, 95% confidence interval [CI] 1.23-2.26) and possibly diabetes (RR 2.25, 95% CI 0.53-9.50), was present among TCDD/HCD-exposed workers. Risks tended to be higher 10 to 19 years after first exposure and for those exposed for a duration of 10 to 19 years. Mortality from suicide was comparable to that for the general population for all workers exposed to herbicides or chlorophenols and was associated with short latency and duration of exposure. More refined investigations of the ischemic heart disease and TCDD/HCD exposure association are warranted.

Original languageEnglish
Pages (from-to)645-653
Number of pages9
JournalEnvironmental Health Perspectives
Volume106
Issue numberSUPPL. 2
Publication statusPublished - 1998

Fingerprint

Chlorophenols
Dioxins
chlorophenol
Herbicides
dioxin
herbicide
Cohort Studies
mortality
Mortality
Myocardial Ischemia
cardiovascular disease
Healthy Worker Effect
Confidence Intervals
Cerebrovascular Disorders
Suicide
confidence interval
Medical problems
Heart Rate
Regression Analysis
Polychlorinated Dibenzodioxins

Keywords

  • Cardiovascular diseases
  • Diabetes
  • Dioxin
  • Epidemiology
  • Herbicides
  • Mortality

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Vena, J., Boffetta, P., Becher, H., Benn, T., Bas Bueno-de-Mesquita, H., Coggon, D., ... Kogevinas, M. (1998). Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. Environmental Health Perspectives, 106(SUPPL. 2), 645-653.

Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. / Vena, John; Boffetta, Paolo; Becher, Heiko; Benn, Trevor; Bas Bueno-de-Mesquita, H.; Coggon, David; Colin, Didier; Flesch-Janys, Dieter; Green, Lois; Kauppinen, Timo; Littorin, Margareta; Lynge, Elsebeth; Mathews, John D.; Neuberger, Manfred; Pearce, Neil; Pesatori, Angela C.; Saracci, Rodolfo; Steenland, Kyle; Kogevinas, Manolis.

In: Environmental Health Perspectives, Vol. 106, No. SUPPL. 2, 1998, p. 645-653.

Research output: Contribution to journalArticle

Vena, J, Boffetta, P, Becher, H, Benn, T, Bas Bueno-de-Mesquita, H, Coggon, D, Colin, D, Flesch-Janys, D, Green, L, Kauppinen, T, Littorin, M, Lynge, E, Mathews, JD, Neuberger, M, Pearce, N, Pesatori, AC, Saracci, R, Steenland, K & Kogevinas, M 1998, 'Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers', Environmental Health Perspectives, vol. 106, no. SUPPL. 2, pp. 645-653.
Vena, John ; Boffetta, Paolo ; Becher, Heiko ; Benn, Trevor ; Bas Bueno-de-Mesquita, H. ; Coggon, David ; Colin, Didier ; Flesch-Janys, Dieter ; Green, Lois ; Kauppinen, Timo ; Littorin, Margareta ; Lynge, Elsebeth ; Mathews, John D. ; Neuberger, Manfred ; Pearce, Neil ; Pesatori, Angela C. ; Saracci, Rodolfo ; Steenland, Kyle ; Kogevinas, Manolis. / Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. In: Environmental Health Perspectives. 1998 ; Vol. 106, No. SUPPL. 2. pp. 645-653.
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