Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study

Isabelle Deltour, Brigitte Schlehofer, Amélie Massardier-Pilonchéry, Klaus Schlaefer, Bruce Armstrong, Graham G Giles, Jack Siemiatycki, Marie-Elise Parent, Daniel Krewski, Mary McBride, Christoffer Johansen, Anssi Auvinen, Tiina Salminen, Martine Hours, Lucile Montestrucq, Maria Blettner, Gabriele Berg-Beckhoff, Siegal Sadetzki, Angela Chetrit, Susanna LagorioIvano Iavarone, Naohito Yamaguchi, Toru Takebayashi, Alistair Woodward, Angus Cook, Tore Tynes, Lars Klaeboe, Maria Feychting Maria Feychting, Stefan Lönn, Sarah Fleming, Anthony J Swerdlow, Minouk J Schoemaker, Monika Moissonnier, Ausrele Kesminiene, Elisabeth Cardis, Joachim Schüz, INTERPHONE Study GroupM3 - doi: 10.5271/sjweh.3781

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure.

METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets.

RESULTS: The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise.

CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

Original languageEnglish
Pages (from-to)183-193
Number of pages11
JournalScandinavian Journal of Work, Environment and Health
Issue number2
Publication statusPublished - 2019

Fingerprint

Acoustic Neuroma
Noise
Odds Ratio
Confidence Intervals
Leisure Activities
Occupational Noise
Occupational Exposure
Logistic Models
Population

Keywords

  • acoustic neuroma
  • case‒control study
  • epidemiology
  • exposure
  • international
  • INTERPHONE
  • loud noise
  • noise
  • noise exposure
  • vestibular schwannoma

Cite this

Deltour, I., Schlehofer, B., Massardier-Pilonchéry, A., Schlaefer, K., Armstrong, B., Giles, G. G., ... 10.5271/sjweh.3781, INTERPHONE. S. G. . D. (2019). Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study. Scandinavian Journal of Work, Environment and Health, (2), 183-193.

Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study. / Deltour, Isabelle; Schlehofer, Brigitte; Massardier-Pilonchéry, Amélie; Schlaefer, Klaus; Armstrong, Bruce; Giles, Graham G; Siemiatycki, Jack; Parent, Marie-Elise; Krewski, Daniel; McBride, Mary; Johansen, Christoffer; Auvinen, Anssi; Salminen, Tiina; Hours, Martine; Montestrucq, Lucile; Blettner, Maria; Berg-Beckhoff, Gabriele; Sadetzki, Siegal; Chetrit, Angela; Lagorio, Susanna; Iavarone, Ivano; Yamaguchi, Naohito; Takebayashi, Toru; Woodward, Alistair; Cook, Angus; Tynes, Tore; Klaeboe, Lars; Maria Feychting, Maria Feychting; Lönn, Stefan; Fleming, Sarah; Swerdlow, Anthony J; Schoemaker, Minouk J; Moissonnier, Monika; Kesminiene, Ausrele; Cardis, Elisabeth; Schüz, Joachim; 10.5271/sjweh.3781, INTERPHONE Study GroupM3 - doi:.

In: Scandinavian Journal of Work, Environment and Health, No. 2, 2019, p. 183-193.

Research output: Contribution to journalArticle

Deltour, I, Schlehofer, B, Massardier-Pilonchéry, A, Schlaefer, K, Armstrong, B, Giles, GG, Siemiatycki, J, Parent, M-E, Krewski, D, McBride, M, Johansen, C, Auvinen, A, Salminen, T, Hours, M, Montestrucq, L, Blettner, M, Berg-Beckhoff, G, Sadetzki, S, Chetrit, A, Lagorio, S, Iavarone, I, Yamaguchi, N, Takebayashi, T, Woodward, A, Cook, A, Tynes, T, Klaeboe, L, Maria Feychting, MF, Lönn, S, Fleming, S, Swerdlow, AJ, Schoemaker, MJ, Moissonnier, M, Kesminiene, A, Cardis, E, Schüz, J & 10.5271/sjweh.3781, INTERPHONESGD 2019, 'Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study', Scandinavian Journal of Work, Environment and Health, no. 2, pp. 183-193.
Deltour, Isabelle ; Schlehofer, Brigitte ; Massardier-Pilonchéry, Amélie ; Schlaefer, Klaus ; Armstrong, Bruce ; Giles, Graham G ; Siemiatycki, Jack ; Parent, Marie-Elise ; Krewski, Daniel ; McBride, Mary ; Johansen, Christoffer ; Auvinen, Anssi ; Salminen, Tiina ; Hours, Martine ; Montestrucq, Lucile ; Blettner, Maria ; Berg-Beckhoff, Gabriele ; Sadetzki, Siegal ; Chetrit, Angela ; Lagorio, Susanna ; Iavarone, Ivano ; Yamaguchi, Naohito ; Takebayashi, Toru ; Woodward, Alistair ; Cook, Angus ; Tynes, Tore ; Klaeboe, Lars ; Maria Feychting, Maria Feychting ; Lönn, Stefan ; Fleming, Sarah ; Swerdlow, Anthony J ; Schoemaker, Minouk J ; Moissonnier, Monika ; Kesminiene, Ausrele ; Cardis, Elisabeth ; Schüz, Joachim ; 10.5271/sjweh.3781, INTERPHONE Study GroupM3 - doi:. / Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study. In: Scandinavian Journal of Work, Environment and Health. 2019 ; No. 2. pp. 183-193.
@article{1dc712482b014277a3112316540f0648,
title = "Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study",
abstract = "OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95{\%} confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. RESULTS: The OR for total work and leisure noise exposure was 1.6 (95{\%} CI 1.4–1.9). OR were 1.5 (95{\%} CI 1.3–1.9) for only occupational noise, 1.9 (95{\%} CI 1.4–2.6) for only leisure noise and 1.7 (95{\%} CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.",
keywords = "acoustic neuroma, case‒control study, epidemiology, exposure, international, INTERPHONE, loud noise, noise, noise exposure, vestibular schwannoma",
author = "Isabelle Deltour and Brigitte Schlehofer and Am{\'e}lie Massardier-Pilonch{\'e}ry and Klaus Schlaefer and Bruce Armstrong and Giles, {Graham G} and Jack Siemiatycki and Marie-Elise Parent and Daniel Krewski and Mary McBride and Christoffer Johansen and Anssi Auvinen and Tiina Salminen and Martine Hours and Lucile Montestrucq and Maria Blettner and Gabriele Berg-Beckhoff and Siegal Sadetzki and Angela Chetrit and Susanna Lagorio and Ivano Iavarone and Naohito Yamaguchi and Toru Takebayashi and Alistair Woodward and Angus Cook and Tore Tynes and Lars Klaeboe and {Maria Feychting}, {Maria Feychting} and Stefan L{\"o}nn and Sarah Fleming and Swerdlow, {Anthony J} and Schoemaker, {Minouk J} and Monika Moissonnier and Ausrele Kesminiene and Elisabeth Cardis and Joachim Sch{\"u}z and 10.5271/sjweh.3781, {INTERPHONE Study GroupM3 - doi:}",
year = "2019",
language = "English",
pages = "183--193",
journal = "Scandinavian Journal of Work, Environment and Health",
issn = "0355-3140",
publisher = "Nordic Association of Occupational Safety and Health",
number = "2",

}

TY - JOUR

T1 - Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study

AU - Deltour, Isabelle

AU - Schlehofer, Brigitte

AU - Massardier-Pilonchéry, Amélie

AU - Schlaefer, Klaus

AU - Armstrong, Bruce

AU - Giles, Graham G

AU - Siemiatycki, Jack

AU - Parent, Marie-Elise

AU - Krewski, Daniel

AU - McBride, Mary

AU - Johansen, Christoffer

AU - Auvinen, Anssi

AU - Salminen, Tiina

AU - Hours, Martine

AU - Montestrucq, Lucile

AU - Blettner, Maria

AU - Berg-Beckhoff, Gabriele

AU - Sadetzki, Siegal

AU - Chetrit, Angela

AU - Lagorio, Susanna

AU - Iavarone, Ivano

AU - Yamaguchi, Naohito

AU - Takebayashi, Toru

AU - Woodward, Alistair

AU - Cook, Angus

AU - Tynes, Tore

AU - Klaeboe, Lars

AU - Maria Feychting, Maria Feychting

AU - Lönn, Stefan

AU - Fleming, Sarah

AU - Swerdlow, Anthony J

AU - Schoemaker, Minouk J

AU - Moissonnier, Monika

AU - Kesminiene, Ausrele

AU - Cardis, Elisabeth

AU - Schüz, Joachim

AU - 10.5271/sjweh.3781, INTERPHONE Study GroupM3 - doi:

PY - 2019

Y1 - 2019

N2 - OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. RESULTS: The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

AB - OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. RESULTS: The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.

KW - acoustic neuroma

KW - case‒control study

KW - epidemiology

KW - exposure

KW - international

KW - INTERPHONE

KW - loud noise

KW - noise

KW - noise exposure

KW - vestibular schwannoma

M3 - Article

SP - 183

EP - 193

JO - Scandinavian Journal of Work, Environment and Health

JF - Scandinavian Journal of Work, Environment and Health

SN - 0355-3140

IS - 2

ER -