TY - JOUR
T1 - Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study
AU - Deltour, Isabelle
AU - Schlehofer, Brigitte
AU - Massardier-Pilonchéry, Amélie
AU - Schlaefer, Klaus
AU - Armstrong, Bruce
AU - Giles, Graham G
AU - Siemiatycki, Jack
AU - Parent, Marie-Elise
AU - Krewski, Daniel
AU - McBride, Mary
AU - Johansen, Christoffer
AU - Auvinen, Anssi
AU - Salminen, Tiina
AU - Hours, Martine
AU - Montestrucq, Lucile
AU - Blettner, Maria
AU - Berg-Beckhoff, Gabriele
AU - Sadetzki, Siegal
AU - Chetrit, Angela
AU - Lagorio, Susanna
AU - Iavarone, Ivano
AU - Yamaguchi, Naohito
AU - Takebayashi, Toru
AU - Woodward, Alistair
AU - Cook, Angus
AU - Tynes, Tore
AU - Klaeboe, Lars
AU - Maria Feychting, Maria Feychting
AU - Lönn, Stefan
AU - Fleming, Sarah
AU - Swerdlow, Anthony J
AU - Schoemaker, Minouk J
AU - Moissonnier, Monika
AU - Kesminiene, Ausrele
AU - Cardis, Elisabeth
AU - Schüz, Joachim
AU - 10.5271/sjweh.3781, INTERPHONE Study GroupM3 - doi:
PY - 2019
Y1 - 2019
N2 - OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. RESULTS: The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.
AB - OBJECTIVE: Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000–2004. In this paper, we report the results of analyses on the association between VS and self-reported loud noise exposure. METHODS: Self-reported noise exposure was analyzed in 1024 VS cases and 1984 matched controls. Life-long noise exposure was estimated through detailed questions. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using adjusted conditional logistic regression for matched sets. RESULTS: The OR for total work and leisure noise exposure was 1.6 (95% CI 1.4–1.9). OR were 1.5 (95% CI 1.3–1.9) for only occupational noise, 1.9 (95% CI 1.4–2.6) for only leisure noise and 1.7 (95% CI 1.2–2.2) for exposure in both contexts. OR increased slightly with increasing lag-time. For occupational exposures, duration, time since exposure start and a metric combining lifetime duration and weekly exposure showed significant trends of increasing risk with increasing exposure. OR did not differ markedly by source or other characteristics of noise. CONCLUSION: The consistent associations seen are likely to reflect either recall bias or a causal association, or potentially indicate a mixture of both.
KW - acoustic neuroma
KW - case‒control study
KW - epidemiology
KW - exposure
KW - international
KW - INTERPHONE
KW - loud noise
KW - noise
KW - noise exposure
KW - vestibular schwannoma
M3 - Article
SP - 183
EP - 193
JO - Scandinavian Journal of Work, Environment and Health
JF - Scandinavian Journal of Work, Environment and Health
SN - 0355-3140
IS - 2
ER -