Expression and characterization of a dopamine D4R variant associated with delusional disorder

Marie Thérèse Zenner, Maria Nobile, Robert Henningsen, Enrico Smeraldi, Olivier Civelli, Deborah S. Hartman, Marco Catalano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Multiple genetic polymorphisms of the human dopamine D4 receptor (hD4R) have been identified including a 12 bp repeat in exon 1 associated with a psychotic condition called delusional disorder. Competition binding assays revealed minor pharmacological differences between the recombinant A1 (normal) and A2 (delusional) proteins with respect to quinpirole and the antipsychotic clozapine, however no functional differences mere detected for receptor activation by dopamine, epinephrine, or norepinephrine. Our results suggest that this polymorphism may only confer susceptibility to delusional disorder in combination with other genetic or environmental factors.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalFEBS Letters
Volume422
Issue number2
DOIs
Publication statusPublished - Jan 30 1998

Fingerprint

Paranoid Schizophrenia
Polymorphism
Dopamine
Dopamine D4 Receptors
Quinpirole
Clozapine
Dopamine Receptors
Genetic Polymorphisms
varespladib methyl
Antipsychotic Agents
Epinephrine
Exons
Assays
Norepinephrine
Chemical activation
Pharmacology
Proteins

Keywords

  • Antidepressant
  • Antipsychotic
  • DFR1
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Zenner, M. T., Nobile, M., Henningsen, R., Smeraldi, E., Civelli, O., Hartman, D. S., & Catalano, M. (1998). Expression and characterization of a dopamine D4R variant associated with delusional disorder. FEBS Letters, 422(2), 146-150. https://doi.org/10.1016/S0014-5793(97)01617-7

Expression and characterization of a dopamine D4R variant associated with delusional disorder. / Zenner, Marie Thérèse; Nobile, Maria; Henningsen, Robert; Smeraldi, Enrico; Civelli, Olivier; Hartman, Deborah S.; Catalano, Marco.

In: FEBS Letters, Vol. 422, No. 2, 30.01.1998, p. 146-150.

Research output: Contribution to journalArticle

Zenner, MT, Nobile, M, Henningsen, R, Smeraldi, E, Civelli, O, Hartman, DS & Catalano, M 1998, 'Expression and characterization of a dopamine D4R variant associated with delusional disorder', FEBS Letters, vol. 422, no. 2, pp. 146-150. https://doi.org/10.1016/S0014-5793(97)01617-7
Zenner, Marie Thérèse ; Nobile, Maria ; Henningsen, Robert ; Smeraldi, Enrico ; Civelli, Olivier ; Hartman, Deborah S. ; Catalano, Marco. / Expression and characterization of a dopamine D4R variant associated with delusional disorder. In: FEBS Letters. 1998 ; Vol. 422, No. 2. pp. 146-150.
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