Expression and characterization of a dopamine D4R variant associated with delusional disorder

Marie Thérèse Zenner, Maria Nobile, Robert Henningsen, Enrico Smeraldi, Olivier Civelli, Deborah S. Hartman, Marco Catalano

Research output: Contribution to journalArticle

Abstract

Multiple genetic polymorphisms of the human dopamine D4 receptor (hD4R) have been identified including a 12 bp repeat in exon 1 associated with a psychotic condition called delusional disorder. Competition binding assays revealed minor pharmacological differences between the recombinant A1 (normal) and A2 (delusional) proteins with respect to quinpirole and the antipsychotic clozapine, however no functional differences mere detected for receptor activation by dopamine, epinephrine, or norepinephrine. Our results suggest that this polymorphism may only confer susceptibility to delusional disorder in combination with other genetic or environmental factors.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalFEBS Letters
Volume422
Issue number2
DOIs
Publication statusPublished - Jan 30 1998

    Fingerprint

Keywords

  • Antidepressant
  • Antipsychotic
  • DFR1
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Zenner, M. T., Nobile, M., Henningsen, R., Smeraldi, E., Civelli, O., Hartman, D. S., & Catalano, M. (1998). Expression and characterization of a dopamine D4R variant associated with delusional disorder. FEBS Letters, 422(2), 146-150. https://doi.org/10.1016/S0014-5793(97)01617-7