Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer

P. Parrella, P. Mazzarelli, E. Signori, G. Perrone, G. F. Marangi, C. Rabitti, M. Delfino, M. Prencipe, A. P. Gallo, M. Rinaldi, G. Fabbrocini, S. Delfino, P. Persichetti, V. M. Fazio

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Abstract

Background: Experimental data suggest that exposure to ultraviolet radiation may indirectly induce DNA double-strand breaks. Aim: To investigate the contribution of the non-homologous end-joining repair pathway in basal and squamous cell carcinomas. Methods: Levels of Ku70 and Ku80 proteins were determined by immunohistochemical analysis and Ku70-Ku80 heterodimer-binding activity by electrophoretic mobility shift assay. Matched pathological normal margins and skin from healthy people were used as controls. Results: A significant increase in Ku70 and Ku80 protein levels was found for both tumour types as compared with normal skin (p

Original languageEnglish
Pages (from-to)1181-1185
Number of pages5
JournalJournal of Clinical Pathology
Volume59
Issue number11
DOIs
Publication statusPublished - Nov 2006

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Parrella, P., Mazzarelli, P., Signori, E., Perrone, G., Marangi, G. F., Rabitti, C., Delfino, M., Prencipe, M., Gallo, A. P., Rinaldi, M., Fabbrocini, G., Delfino, S., Persichetti, P., & Fazio, V. M. (2006). Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer. Journal of Clinical Pathology, 59(11), 1181-1185. https://doi.org/10.1136/jcp.2005.031088