Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients

I. Casciano, K. Mazzocco, L. Boni, G. Pagnan, B. Banelli, G. Allemanni, M. Ponzoni, G. P. Tonini, M. Romani

Research output: Contribution to journalArticle

Abstract

The p73 gene is a p53 homologue which induces apoptosis and inhibits cell proliferation. Although p73 maps at 1p36.3 and is frequently deleted in neuroblastoma (NB), it does not act as a classic oncosuppressor gene. In developing sympathetic neurons of mice, p73 is predominantly expressed as a truncated anti-apoptotic isoform (ΔNp73), which antagonizes both p53 and the full-length p73 protein (TAp73). This suggests that p73 may be part of a complex tumor-control mechanism. To determine the role of ΔNp73 in NB we analyzed the pattern of expression of this gene in vivo and evaluated the prognostic significance of its expression. Our results indicate that ΔNp73 expression is associated with reduced apoptosis in a NB tumor tissue. Expression of this variant in NB patients significantly correlates with age at diagnosis and VMA urinary excretion. Moreover it is strongly associated with reduced survival (HR=7.93; P

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalCell Death and Differentiation
Volume9
Issue number3
DOIs
Publication statusPublished - 2002

Keywords

  • Apoptosis
  • Neuroblastoma
  • p73
  • Prognostic factors

ASJC Scopus subject areas

  • Cell Biology

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