Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice

Monica Fedele, Rosa Visone, Ivana De Martino, Dario Palmieri, Teresa Valentino, Francesco Esposito, Andres Klein-Szanto, Claudio Arra, Andrea Ciarmiello, Carlo M. Croce, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

HMGA1 gene rearrangements have been frequently described in human lipomas. In vitro studies suggest that HMGA1 proteins have a negative role in the control of adipocyte cell growth, and that HMGA1 gene truncation acts in a dominant-negative fashion. Therefore, to define better the role of the HMGA1 alterations in the generation of human lipomas, we generated mice carrying an Hmga1b truncated (Hmga1b/T) gene. These mice develop a giant phenotype together with a drastic expansion of the retroperitoneal and subcutaneous white adipose tissue. We show that the activation of the E2F pathway likely accounts, at least in part, for this phenotype. Interestingly, the Hmga1b/T mice also develop B-cell lymphomas similar to that occurring in Hmga1-knockout mice, supporting a dominant-negative role of the Hmga1b/T mutant also in vivo.

Original languageEnglish
Pages (from-to)470-478
Number of pages9
JournalEuropean Journal of Cancer
Volume47
Issue number3
DOIs
Publication statusPublished - Feb 2011

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Keywords

  • Adipogenesis
  • E2F1
  • Experimental animal models
  • High Mobility Group proteins
  • Lymphoma
  • Oncogene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fedele, M., Visone, R., De Martino, I., Palmieri, D., Valentino, T., Esposito, F., Klein-Szanto, A., Arra, C., Ciarmiello, A., Croce, C. M., & Fusco, A. (2011). Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice. European Journal of Cancer, 47(3), 470-478. https://doi.org/10.1016/j.ejca.2010.09.045