Expression of Ambra1 in mouse brain during physiological and alzheimer type aging

Sara Sepe, Roberta Nardacci, Francesca Fanelli, Pamela Rosso, Cinzia Bernardi, Francesco Cecconi, Pier G. Mastroberardino, Mauro Piacentini, Sandra Moreno

Research output: Contribution to journalArticle

Abstract

Autophagy is a major protein degradation pathway, essential for stress-induced and constitutive protein turnover. In nervous tissue, autophagy is constitutively active and crucial to neuronal survival. The efficiency of the autophagic pathway reportedly undergoes age-related decline, and autophagy defects are observed in neurodegenerative diseases. Since Ambra1 plays a fundamental role in regulating the autophagic process in developing nervous tissue, we investigated the expression of this protein in mature mouse brain and during physiological and Alzheimer type aging. The present study accomplished the first complete map of Ambra1 protein distribution in the various brain areas, and highlights differential expression in neuronal/glial cell populations. Differences in Ambra1 content are possibly related to specific neuronal features and properties, particularly concerning susceptibility to neurodegeneration. Furthermore, the analysis of Ambra1 expression in physiological and pathological brain aging supports important, though conflicting, functions of autophagy in neurodegenerative processes. Thus, novel therapeutic approaches, based on autophagy modulation, should also take into account the age-dependent roles of this mechanism in establishing, promoting, or counteracting neurodegeneration.

Original languageEnglish
Pages (from-to)96-108
Number of pages13
JournalNeurobiology of Aging
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Aging
  • Alzheimer's disease
  • Ambra1
  • Autophagy
  • Brain
  • Glia
  • Hippocampus
  • Neocortex
  • Neurodegeneration
  • Neuron
  • Tg2576

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

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