Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms

Teresa Marafioti, Stefano Ascani, Karen Pulford, Elena Sabattini, Milena Piccioli, Margaret Jones, Pier Luigi Zinzani, Georges Delsol, David Y. Mason, Stefano A. Pileri

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Abstract

In this study we have investigated the expression of three B-cell-associated transcription factors in normal lymphoid tissue and in T-cell neoplasms (three cell lines, and more than 50 biopsy samples). Nuclear OCT-1 immunoreactivity was seen in normal B cells, in many extrafollicular T cells, and in a heterogeneous pattern (ranging in intensity from weak to moderate) in most T-cell neoplasms. OCT-2 immunostaining was primarily restricted in normal lymphoid tissue to B cells, and was absent from most T-cell neoplasms. In contrast, immunostaining for BOB-1/OCA-B - essentially restricted to B cells in normal lymphoid tissue, with the exception of activated T-lymphocytes-was seen in all of the T-cell lines tested and the majority of the tumor cells in all categories of T-cell lymphoma. Thus labeling for each of these three B-cell-associated transcription factors can be seen to varying degrees in T-cell neoplasms. However, the high frequency of BOB-1 expression in T-cell neoplasms, in contrast to its absence from resting peripheral T cells, suggests that its expression might be a prerequisite for neoplastic transformation, and prompts a search for the transcriptional target(s) of this factor in T cells.

Original languageEnglish
Pages (from-to)861-871
Number of pages11
JournalAmerican Journal of Pathology
Volume162
Issue number3
Publication statusPublished - Mar 1 2003

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B-Lymphocytes
Transcription Factors
T-Lymphocytes
Neoplasms
Lymphoid Tissue
TCF Transcription Factors
Cell Line
T-Cell Lymphoma
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Marafioti, T., Ascani, S., Pulford, K., Sabattini, E., Piccioli, M., Jones, M., ... Pileri, S. A. (2003). Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms. American Journal of Pathology, 162(3), 861-871.

Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms. / Marafioti, Teresa; Ascani, Stefano; Pulford, Karen; Sabattini, Elena; Piccioli, Milena; Jones, Margaret; Zinzani, Pier Luigi; Delsol, Georges; Mason, David Y.; Pileri, Stefano A.

In: American Journal of Pathology, Vol. 162, No. 3, 01.03.2003, p. 861-871.

Research output: Contribution to journalArticle

Marafioti, T, Ascani, S, Pulford, K, Sabattini, E, Piccioli, M, Jones, M, Zinzani, PL, Delsol, G, Mason, DY & Pileri, SA 2003, 'Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms', American Journal of Pathology, vol. 162, no. 3, pp. 861-871.
Marafioti T, Ascani S, Pulford K, Sabattini E, Piccioli M, Jones M et al. Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms. American Journal of Pathology. 2003 Mar 1;162(3):861-871.
Marafioti, Teresa ; Ascani, Stefano ; Pulford, Karen ; Sabattini, Elena ; Piccioli, Milena ; Jones, Margaret ; Zinzani, Pier Luigi ; Delsol, Georges ; Mason, David Y. ; Pileri, Stefano A. / Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms. In: American Journal of Pathology. 2003 ; Vol. 162, No. 3. pp. 861-871.
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