Expression of B-lymphocyte-associated transcription factors in human T-cell neoplasms

Teresa Marafioti, Stefano Ascani, Karen Pulford, Elena Sabattini, Milena Piccioli, Margaret Jones, Pier Luigi Zinzani, Georges Delsol, David Y. Mason, Stefano A. Pileri

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we have investigated the expression of three B-cell-associated transcription factors in normal lymphoid tissue and in T-cell neoplasms (three cell lines, and more than 50 biopsy samples). Nuclear OCT-1 immunoreactivity was seen in normal B cells, in many extrafollicular T cells, and in a heterogeneous pattern (ranging in intensity from weak to moderate) in most T-cell neoplasms. OCT-2 immunostaining was primarily restricted in normal lymphoid tissue to B cells, and was absent from most T-cell neoplasms. In contrast, immunostaining for BOB-1/OCA-B - essentially restricted to B cells in normal lymphoid tissue, with the exception of activated T-lymphocytes-was seen in all of the T-cell lines tested and the majority of the tumor cells in all categories of T-cell lymphoma. Thus labeling for each of these three B-cell-associated transcription factors can be seen to varying degrees in T-cell neoplasms. However, the high frequency of BOB-1 expression in T-cell neoplasms, in contrast to its absence from resting peripheral T cells, suggests that its expression might be a prerequisite for neoplastic transformation, and prompts a search for the transcriptional target(s) of this factor in T cells.

Original languageEnglish
Pages (from-to)861-871
Number of pages11
JournalAmerican Journal of Pathology
Volume162
Issue number3
Publication statusPublished - Mar 1 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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