Abstract
Objectives: To determine whether COX-2, bcl-2 and neoangiogenesis are related to human prostate cancer relapse after definitive surgical treatment and progression toward androgen independence and to evaluate the association between the patterns of these tumoral biomarkers and other standard clinico-pathological parameters (such as Gleason score, PSA, TNM stage). Materials and methods: We retrospectively analyzed the records on 126 prostate cancer samples from patients treated at our University Hospital from 1995 to 2002. The 72 patients with clinically localized disease (group 1) had undergone radical prostatectomy. Another 54 patients (group 2) had metastatic androgen-independent disease. Archived material relating to the subjects was then immunostained for bcl-2, COX-2 and CD-31, using an anti-bcl-2 monoclonal primary antibody, an anti-COX-2 polyclonal rabbit antibody and an anti-CD-31 monoclonal mouse antibody to evaluate neoangiogenesis (MVD, microvessel density). Results: We found that bcl-2, COX-2 and MVD expression increased from group 1 to group 2. The intergroup difference was significant only for high MVD (P
| Original language | English |
|---|---|
| Pages (from-to) | 54-59 |
| Number of pages | 6 |
| Journal | Prostate Cancer and Prostatic Diseases |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 2005 |
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Keywords
- Bcl-2
- COX-2
- MVD
- Prognostic factors
ASJC Scopus subject areas
- Oncology
- Urology
Cite this
Expression of biomarkers modulating prostate cancer progression : Implications in the treatment of the disease. / Di Lorenzo, Giuseppe; De Placido, S.; Autorino, R.; De Laurentiis, M.; Mignogna, C.; D'Armiento, M.; Tortora, G.; De Rosa, G.; D'Armiento, M.; De Sio, M.; Bianco, A. R.; D'Armiento, F. P.
In: Prostate Cancer and Prostatic Diseases, Vol. 8, No. 1, 03.2005, p. 54-59.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of biomarkers modulating prostate cancer progression
T2 - Implications in the treatment of the disease
AU - Di Lorenzo, Giuseppe
AU - De Placido, S.
AU - Autorino, R.
AU - De Laurentiis, M.
AU - Mignogna, C.
AU - D'Armiento, M.
AU - Tortora, G.
AU - De Rosa, G.
AU - D'Armiento, M.
AU - De Sio, M.
AU - Bianco, A. R.
AU - D'Armiento, F. P.
PY - 2005/3
Y1 - 2005/3
N2 - Objectives: To determine whether COX-2, bcl-2 and neoangiogenesis are related to human prostate cancer relapse after definitive surgical treatment and progression toward androgen independence and to evaluate the association between the patterns of these tumoral biomarkers and other standard clinico-pathological parameters (such as Gleason score, PSA, TNM stage). Materials and methods: We retrospectively analyzed the records on 126 prostate cancer samples from patients treated at our University Hospital from 1995 to 2002. The 72 patients with clinically localized disease (group 1) had undergone radical prostatectomy. Another 54 patients (group 2) had metastatic androgen-independent disease. Archived material relating to the subjects was then immunostained for bcl-2, COX-2 and CD-31, using an anti-bcl-2 monoclonal primary antibody, an anti-COX-2 polyclonal rabbit antibody and an anti-CD-31 monoclonal mouse antibody to evaluate neoangiogenesis (MVD, microvessel density). Results: We found that bcl-2, COX-2 and MVD expression increased from group 1 to group 2. The intergroup difference was significant only for high MVD (P
AB - Objectives: To determine whether COX-2, bcl-2 and neoangiogenesis are related to human prostate cancer relapse after definitive surgical treatment and progression toward androgen independence and to evaluate the association between the patterns of these tumoral biomarkers and other standard clinico-pathological parameters (such as Gleason score, PSA, TNM stage). Materials and methods: We retrospectively analyzed the records on 126 prostate cancer samples from patients treated at our University Hospital from 1995 to 2002. The 72 patients with clinically localized disease (group 1) had undergone radical prostatectomy. Another 54 patients (group 2) had metastatic androgen-independent disease. Archived material relating to the subjects was then immunostained for bcl-2, COX-2 and CD-31, using an anti-bcl-2 monoclonal primary antibody, an anti-COX-2 polyclonal rabbit antibody and an anti-CD-31 monoclonal mouse antibody to evaluate neoangiogenesis (MVD, microvessel density). Results: We found that bcl-2, COX-2 and MVD expression increased from group 1 to group 2. The intergroup difference was significant only for high MVD (P
KW - Bcl-2
KW - COX-2
KW - MVD
KW - Prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=20444504317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20444504317&partnerID=8YFLogxK
U2 - 10.1038/sj.pcan.4500768
DO - 10.1038/sj.pcan.4500768
M3 - Article
C2 - 15655565
AN - SCOPUS:20444504317
VL - 8
SP - 54
EP - 59
JO - Prostate Cancer and Prostatic Diseases
JF - Prostate Cancer and Prostatic Diseases
SN - 1365-7852
IS - 1
ER -