TY - JOUR
T1 - Expression of cancer stem cell biomarkers as a tool for a correct therapeutic approach to hepatocellular carcinoma
AU - Romano, Maurizio
AU - De Francesco, Francesco
AU - Pirozzi, Giuseppe
AU - Gringeri, Enrico
AU - Boetto, Riccardo
AU - Di Domenico, Marina
AU - Zavan, Barbara
AU - Ferraro, Giuseppe A.
AU - Cillo, Umberto
PY - 2015
Y1 - 2015
N2 - Liver cancer is the fifth most commonly diagnosed malignancy and the second most frequent cause of cancer death in men worldwide. Amongst liver cancers, hepatocellular carcinoma (HCC) represents the major histological subtype and it is one of the most common malignant human tumors worldwide. Research into the molecular biology of hepatocarcinogenesis has identified several biomarkers, which could provide additional informations in order to better understand the biology of HCC. A large number of biomarkers have been shown to have potential predictive significance and a wide variety of molecular markers have been proven to be excellent diagnostic tools for HCC but it is difficult to characterize HCC with a single biomarker. Thus, signatures of a combination of biomarkers may be more valuable for the diagnosis, staging and prognosis of HCC. Specifically, a correlation of HCC-CSCs phenotype to specific hepatic cancer subtypes and to specific clinical and pathological features has not yet been reported in human liver tumors. In this view we will first discuss the possible sources of liver stem cells and their relation with liver cancer development and we will secondly focus on the prognostic significance of clinical and pathological features of HCC.
AB - Liver cancer is the fifth most commonly diagnosed malignancy and the second most frequent cause of cancer death in men worldwide. Amongst liver cancers, hepatocellular carcinoma (HCC) represents the major histological subtype and it is one of the most common malignant human tumors worldwide. Research into the molecular biology of hepatocarcinogenesis has identified several biomarkers, which could provide additional informations in order to better understand the biology of HCC. A large number of biomarkers have been shown to have potential predictive significance and a wide variety of molecular markers have been proven to be excellent diagnostic tools for HCC but it is difficult to characterize HCC with a single biomarker. Thus, signatures of a combination of biomarkers may be more valuable for the diagnosis, staging and prognosis of HCC. Specifically, a correlation of HCC-CSCs phenotype to specific hepatic cancer subtypes and to specific clinical and pathological features has not yet been reported in human liver tumors. In this view we will first discuss the possible sources of liver stem cells and their relation with liver cancer development and we will secondly focus on the prognostic significance of clinical and pathological features of HCC.
KW - Biomarkers
KW - Clinic-pathological
KW - Early diagnosis
KW - Hepatocellular carcinoma
KW - Prognosis
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U2 - 10.18632/oncoscience.163
DO - 10.18632/oncoscience.163
M3 - Article
AN - SCOPUS:84952872085
VL - 2
SP - 443
EP - 456
JO - Oncoscience
JF - Oncoscience
SN - 2331-4737
IS - 5
ER -