Expression of CD40 has no predictive value in soft tissue sarcomas

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Abstract

Background: CD40, a member of the tumor necrosis factor receptor superfamily, is capable of mediating the induction of apoptosis in tumors including sarcomas. The expression of proapoptotic receptor contribute to the induction of apoptosis by chemotherapeutic drugs. The present study was undertaken to determine if there is a correlation between the expression of CD40 in spindle-cell sarcomas and the response to epirubicin and ifosfamide chemotherapy. Patients and Methods: Immunohistochemical analysis of CD40 expression was performed on 59 paraffin-embedded archival tissues. Evaluation of objective tumor response was carried out according to the WHO criteria. Correlations with response to chemotherapy and baseline patients' characteristics were investigated using Chisquare tests. Results: Positive CD40 staining was observed in 42 tumors; it was expressed in

Original languageEnglish
Pages (from-to)1597-1604
Number of pages8
JournalAnticancer Research
Volume23
Issue number2 B
Publication statusPublished - Mar 2003

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Keywords

  • CD40
  • Chemotherapy
  • Epirubicin
  • Ifosfamide
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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