Abstract
CD44 is an ubiquitous surface molecule that exists as a number of isoforms generated by alternative splicing of ten variant exons. Variant forms are upregulated in vitro upon treatment with cytokines and have been reported to be involved in neoplastic transformation and tumor progression in rat and human tissue. We have analysed hyperproliferative disorders and a large number of primary skin tumors and metastases by immunohistochemistry for the expression of CD44 isoforms containing exons 4v, 6v or 9v. Upregulation of all isoforms accompanied hyperproliferative disorders. Conversely, down-regulation of CD44 molecules expression was observed in primary skin tumors and metastases.
| Original language | English |
|---|---|
| Pages (from-to) | 398-406 |
| Number of pages | 9 |
| Journal | European Journal of Dermatology |
| Volume | 5 |
| Issue number | 5 |
| Publication status | Published - 1995 |
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Keywords
- CD44
- Metastasis
- Skin
- Tumor
ASJC Scopus subject areas
- Dermatology
Cite this
Expression of CD44 standard and variant forms in skin tumors. Loss of CD44 correlates with aggressive potential. / Guttinger, M.; Sutti, F.; Barnier, C.; McKay, C.; Berti, E.
In: European Journal of Dermatology, Vol. 5, No. 5, 1995, p. 398-406.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression of CD44 standard and variant forms in skin tumors. Loss of CD44 correlates with aggressive potential
AU - Guttinger, M.
AU - Sutti, F.
AU - Barnier, C.
AU - McKay, C.
AU - Berti, E.
PY - 1995
Y1 - 1995
N2 - CD44 is an ubiquitous surface molecule that exists as a number of isoforms generated by alternative splicing of ten variant exons. Variant forms are upregulated in vitro upon treatment with cytokines and have been reported to be involved in neoplastic transformation and tumor progression in rat and human tissue. We have analysed hyperproliferative disorders and a large number of primary skin tumors and metastases by immunohistochemistry for the expression of CD44 isoforms containing exons 4v, 6v or 9v. Upregulation of all isoforms accompanied hyperproliferative disorders. Conversely, down-regulation of CD44 molecules expression was observed in primary skin tumors and metastases.
AB - CD44 is an ubiquitous surface molecule that exists as a number of isoforms generated by alternative splicing of ten variant exons. Variant forms are upregulated in vitro upon treatment with cytokines and have been reported to be involved in neoplastic transformation and tumor progression in rat and human tissue. We have analysed hyperproliferative disorders and a large number of primary skin tumors and metastases by immunohistochemistry for the expression of CD44 isoforms containing exons 4v, 6v or 9v. Upregulation of all isoforms accompanied hyperproliferative disorders. Conversely, down-regulation of CD44 molecules expression was observed in primary skin tumors and metastases.
KW - CD44
KW - Metastasis
KW - Skin
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=0029081358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029081358&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0029081358
VL - 5
SP - 398
EP - 406
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 5
ER -